Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …

After cardiovascular disease, cancer is the leading cause of death worldwide with
devastating health and economic consequences, particularly in develo** countries. Inter …

Cancer therapies, including conventional chemotherapy, radiation, and molecularly targeted
agents, can lead to tumor eradication through a variety of mechanisms. In addition to their …

The Notch signaling pathway is an architecturally simple signaling mechanism, well known
for its role in cell fate regulation during organ development and in tissue homeostasis. In …

The Notch signaling pathway regulates developmental cell-fate decisions and has recently
also been linked to inflammatory diseases. Although therapies targeting Notch signaling in …

Desmoid tumor (DT) is a rare, soft tissue neoplasm associated with an unpredictable clinical
course. Although lacking metastatic potential, DT is often locally aggressive and invasive …

Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions …

The Notch signaling pathway is a critical player in embryogenesis but also plays various
roles in tumorigenesis, with both tumor suppressor and oncogenic activities. Mutations …

Cardiovascular disease is one of the leading causes of mortality worldwide. Cardiac tissue
engineering strategies focusing on biomaterial scaffolds incorporating cells and growth …

Biomarker-driven targeted therapies are lacking for head and neck squamous cell
carcinoma (HNSCC), which is common and lethal. Efforts to develop such therapies are …