Disturbed mitochondrial dynamics and neurodegenerative disorders
Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …
process, with mitochondrial segments fusing and breaking apart continuously. Strong …
Regulation of mammalian mitochondrial dynamics: opportunities and challenges
Mitochondria are highly dynamic organelles and important for a variety of cellular functions.
They constantly undergo fission and fusion events, referred to as mitochondrial dynamics …
They constantly undergo fission and fusion events, referred to as mitochondrial dynamics …
[HTML][HTML] Apoptotic stress causes mtDNA release during senescence and drives the SASP
Senescent cells drive age-related tissue dysfunction partially through the induction of a
chronic senescence-associated secretory phenotype (SASP). Mitochondria are major …
chronic senescence-associated secretory phenotype (SASP). Mitochondria are major …
Mitochondrial complex I inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells
Inhibition of complex I (CI) of the mitochondrial respiratory chain by BAY 87-2243 ('BAY')
triggers death of BRAF V600E melanoma cell lines and inhibits in vivo tumor growth. Here …
triggers death of BRAF V600E melanoma cell lines and inhibits in vivo tumor growth. Here …
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in
mitochondrial quality control pathways remains unexplored. Here we describe a mechanism …
mitochondrial quality control pathways remains unexplored. Here we describe a mechanism …
Modulating mitofusins to control mitochondrial function and signaling
Mitofusins reside on the outer mitochondrial membrane and regulate mitochondrial fusion, a
physiological process that impacts diverse cellular processes. Mitofusins are activated by …
physiological process that impacts diverse cellular processes. Mitofusins are activated by …
Newly born peroxisomes are a hybrid of mitochondrial and ER-derived pre-peroxisomes
Peroxisomes function together with mitochondria in a number of essential biochemical
pathways, from bile acid synthesis to fatty acid oxidation. Peroxisomes grow and divide from …
pathways, from bile acid synthesis to fatty acid oxidation. Peroxisomes grow and divide from …
Mitochondrial membrane permeabilization in cell death
Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …
Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury
Background—Whether alterations in mitochondrial morphology affect the susceptibility of the
heart to ischemia/reperfusion injury is unknown. We hypothesized that modulating …
heart to ischemia/reperfusion injury is unknown. We hypothesized that modulating …
Mfn2 modulates the UPR and mitochondrial function via repression of PERK
Mitofusin 2 (Mfn2) is a key protein in mitochondrial fusion and it participates in the bridging
of mitochondria to the endoplasmic reticulum (ER). Recent data indicate that Mfn2 ablation …
of mitochondria to the endoplasmic reticulum (ER). Recent data indicate that Mfn2 ablation …