The eight enzymes responsible for the biosynthesis of the three branched-chain amino acids
(l-isoleucine, l-leucine, and l-valine) were identified decades ago using classical genetic …

Novel approaches are required to address the looming threat of pan-resistant Gram-
negative pathogens and forestall the rise of untreatable infections. Unconventional targets …

Disturbances of circulating amino acids have been demonstrated in patients with
Parkinson's disease (PD). However, there have been no consistent results for branched …

Tuberculosis caused by the bacterium, Mycobacterium tuberculosis (Mtb), continues to
remain one of the most devastating infectious diseases afflicting humans. Although there are …

Paenarthrobacter sp. GOM3, which is a strain that represents a new species-specific context
within the genus Paenarthrobacter, is clearly a branched member independent of any group …

Abstract l-Valine, l-isoleucine, and l-leucine are three key proteinogenic amino acids, and
they are also the essential amino acids required for mammalian growth, possessing …

Enzymes of the methylerythritol phosphate pathway of isoprenoid biosynthesis are attractive
anti‐infective drug targets. The last two enzymes of this pathway, IspG and IspH, are [Fe4S4] …

Biological network data, such as metabolic-, signaling-or physical interaction graphs of
proteins are increasingly available in public repositories for important species. Tools for the …

Tuberculosis (TB) remains the leading cause of death due to a single pathogen, accounting
for 1.5 million deaths annually on the global level. Mycobacterium tuberculosis, the …

Microbes are essential to the global ecosystem, but undesirable microbial growth causes
issues ranging from food spoilage and infectious diseases to harmful cyanobacterial …