The aberrant activity of Ras homologous (Rho) family small GTPases (20 human members)
has been implicated in cancer and other human diseases. However, in contrast to the direct …

Rho GTPases oscillate between an inactive GDP-bound state and an active GTP-bound
state. They are activated by Rho Guanine nucleotide Exchange Factors (GEF), which …

Abstract The Rho family of GTPases consists of several small proteins that have been
described as molecular switches, playing important roles in a wide variety of fundamental …

Parkinson's disease (PD) is a neurodegenerative movement disorder characterized with
dopaminergic neuron (DaN) loss within the substantia nigra (SN). Despite bulk studies …

Dendritic arbors are crucial for nervous system assembly, but the intracellular mechanisms
that govern their assembly remain incompletely understood. Here, we show that the …

In the mammalian brain, the majority of excitatory synapses are housed in micron-sized
dendritic protrusions called spines, which can undergo rapid changes in shape and number …

Fast-develo** single-cell technologies create unprecedented opportunities to reveal cell
heterogeneity and diversity. Accurate classification of single cells is a critical prerequisite for …

The dentate gyrus (DG) controls information flow into the hippocampus and is critical for
learning, memory, pattern separation, and spatial coding, while DG dysfunction is …

Abstract Using a 4-hydroxytamoxifen (4OHT)-inducible, conditional Sos1-null mutation, we
analyzed wild-type (WT), single Sos1-KO, Sos2-KO and double Sos1/2 KO primary mouse …

In genome-wide association studies, detecting high-order epistasis is important for
analyzing the occurrence of complex human diseases and explaining missing heritability …