Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
The role of NMDA receptors in Alzheimer's disease
In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
Calcium-permeable ion channels in pain signaling
The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review
AB Petrenko, T Yamakura, H Baba… - Anesthesia & …, 2003 - journals.lww.com
There is accumulating evidence to implicate the importance of N-methyl-d-aspartate (NMDA)
receptors to the induction and maintenance of central sensitization during pain states …
receptors to the induction and maintenance of central sensitization during pain states …
Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system-too little activation is bad, too much is even …
The neurotransmitter glutamate activates several classes of metabotropic receptor and three
major types of ionotropic receptor–α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid …
major types of ionotropic receptor–α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid …
The role of excitotoxicity in neurodegenerative disease: implications for therapy
A Doble - Pharmacology & therapeutics, 1999 - Elsevier
Glutamic acid is the principal excitatory neurotransmitter in the mammalian central nervous
system. Glutamic acid binds to a variety of excitatory amino acid receptors, which are ligand …
system. Glutamic acid binds to a variety of excitatory amino acid receptors, which are ligand …
Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
JE Chatterton, M Awobuluyi, LS Premkumar… - Nature, 2002 - nature.com
The N-methyl-d-aspartate subtype of glutamate receptor (NMDAR) serves critical functions
in physiological and pathological processes in the central nervous system, including …
in physiological and pathological processes in the central nervous system, including …
Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients
Reports of cognitive decline, symptom worsening and brain atrophy in bipolar disorder (BD)
suggest that the disease progresses over time. The worsening neuropathology may involve …
suggest that the disease progresses over time. The worsening neuropathology may involve …
Hypoxia–ischemia in the immature brain
The immature brain has long been considered to be resistant to the damaging effects of
hypoxia and hypoxia–ischemia (H/I). However, it is now appreciated that there are specific …
hypoxia and hypoxia–ischemia (H/I). However, it is now appreciated that there are specific …