Residue mutations and their impact on protein structure and function: detecting beneficial and pathogenic changes
The present review focuses on the evolution of proteins and the impact of amino acid
mutations on function from a structural perspective. Proteins evolve under the law of natural …
mutations on function from a structural perspective. Proteins evolve under the law of natural …
Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms
The heterotrimeric RNA-dependent RNA polymerase of influenza viruses catalyzes RNA
replication and transcription activities in infected cell nuclei. The nucleotide polymerization …
replication and transcription activities in infected cell nuclei. The nucleotide polymerization …
Adaptation of avian influenza A virus polymerase in mammals to overcome the host species barrier
Avian influenza A viruses, such as the highly pathogenic avian H5N1 viruses, sporadically
enter the human population but often do not transmit between individuals. In rare cases …
enter the human population but often do not transmit between individuals. In rare cases …
Stability-activity tradeoffs constrain the adaptive evolution of RubisCO
A well-known case of evolutionary adaptation is that of ribulose-1, 5-bisphosphate
carboxylase (RubisCO), the enzyme responsible for fixation of CO2 during photosynthesis …
carboxylase (RubisCO), the enzyme responsible for fixation of CO2 during photosynthesis …
Viral determinants of influenza A virus host range
AV Cauldwell, JS Long… - Journal of General …, 2014 - microbiologyresearch.org
Typical avian influenza A viruses are restricted from replicating efficiently and causing
disease in humans. However, an avian virus can become adapted to humans by mutating or …
disease in humans. However, an avian virus can become adapted to humans by mutating or …
Identifying genetic markers of adaptation for surveillance of viral host jumps
Adaptation is often thought to affect the likelihood that a virus will be able to successfully
emerge in a new host species. If so, surveillance for genetic markers of adaptation could …
emerge in a new host species. If so, surveillance for genetic markers of adaptation could …
Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers
The emergence of new pandemic influenza A viruses requires overcoming barriers to cross-
species transmission as viruses move from animal reservoirs into humans. This complicated …
species transmission as viruses move from animal reservoirs into humans. This complicated …
Evolution of viral genomes: interplay between selection, recombination, and other forces
Natural selection is a fundamental force sha** organismal evolution, as it both maintains
function and enables adaptation and innovation. Viruses, with their typically short and …
function and enables adaptation and innovation. Viruses, with their typically short and …
Estimating the distribution of selection coefficients from phylogenetic data using sitewise mutation-selection models
Estimation of the distribution of selection coefficients of mutations is a long-standing issue in
molecular evolution. In addition to population-based methods, the distribution can be …
molecular evolution. In addition to population-based methods, the distribution can be …
Complexin-1 enhances ultrasound neurotransmission in the mammalian auditory pathway
Unlike megabats, which rely on well-developed vision, microbats use ultrasonic
echolocation to navigate and locate prey. To study ultrasound perception, here we …
echolocation to navigate and locate prey. To study ultrasound perception, here we …