Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Glutamate receptor ion channels: structure, regulation, and function
The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …
NMDA receptor subunits: diversity, development and disease
N-methyl-d-aspartate receptors (NMDARs) are present at many excitatory glutamate
synapses in the central nervous system and display unique properties that depend on their …
synapses in the central nervous system and display unique properties that depend on their …
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
Ionotropic glutamate receptors mediate most excitatory neurotransmission in the central
nervous system and function by opening a transmembrane ion channel upon binding of …
nervous system and function by opening a transmembrane ion channel upon binding of …
Molecular basis of NMDA receptor functional diversity
NMDA receptors (NMDARs) form glutamate‐gated ion channels widely expressed in the
central nervous system and highly permeable to calcium ions. NMDARs have always …
central nervous system and highly permeable to calcium ions. NMDARs have always …
NMDA receptor subunits: function and pharmacology
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely
expressed in the central nervous system that play key roles in excitatory synaptic …
expressed in the central nervous system that play key roles in excitatory synaptic …
Subunit arrangement and function in NMDA receptors
Excitatory neurotransmission mediated by NMDA (N-methyl-d-aspartate) receptors is
fundamental to the physiology of the mammalian central nervous system. These receptors …
fundamental to the physiology of the mammalian central nervous system. These receptors …
Role of distinct NMDA receptor subtypes at central synapses
Most excitatory synapses in the brain use the neurotransmitter glutamate to carry impulses
between neurons. During fast transmission, glutamate usually activates a mixture of N …
between neurons. During fast transmission, glutamate usually activates a mixture of N …
Ionotropic and metabotropic glutamate receptor structure and pharmacology
Rationale l-Glutamate is the major excitatory neurotransmitter in the central nervous system
(CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor …
(CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor …
NMDA receptors in the central nervous system
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …
component of excitatory neurotransmission in the central nervous system (CNS). They are …