A comprehensive review of human trophoblast fusion models: recent developments and challenges

X Li, ZH Li, YX Wang, TH Liu - Cell Death Discovery, 2023 - nature.com
As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast
layer contributes to a successful pregnancy by secreting hormones necessary for …

Exploring maternal-fetal interface with in vitro placental and trophoblastic models

X Liu, G Wang, H Huang, X Lv, Y Si, L Bai… - Frontiers in Cell and …, 2023 - frontiersin.org
The placenta, being a temporary organ, plays a crucial role in facilitating the exchange of
nutrients and gases between the mother and the fetus during pregnancy. Any abnormalities …

Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape

KM Varberg, EM Dominguez, B Koseva… - Nature …, 2023 - nature.com
The extravillous trophoblast cell lineage is a key feature of placentation and successful
pregnancy. Knowledge of transcriptional regulation driving extravillous trophoblast cell …

TFEB controls expression of human syncytins during cell–cell fusion

MN Esbin, L Dahal, VB Fan, J McKenna… - Genes & …, 2024 - genesdev.cshlp.org
During human development, a temporary organ is formed, the placenta, which invades the
uterine wall to support nutrient, oxygen, and waste exchange between the mother and fetus …

[HTML][HTML] Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy

Q Li, A Sharkey, M Sheridan, E Magistrati… - Cell Stem Cell, 2024 - cell.com
In humans, balanced invasion of trophoblast cells into the uterine mucosa, the decidua, is
critical for successful pregnancy. Evidence suggests that this process is regulated by uterine …

CRISPR screening in human trophoblast stem cells reveals both shared and distinct aspects of human and mouse placental development

T Shimizu, A Oike, EH Kobayashi… - Proceedings of the …, 2023 - National Acad Sciences
The placenta serves as the interface between the mother and fetus, facilitating the exchange
of gases and nutrients between their separate blood circulation systems. Trophoblasts in the …

Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies

E Derisoud, H Jiang, A Zhao… - Human …, 2024 - academic.oup.com
BACKGROUND With increasing significance of developmental programming effects
associated with placental dysfunction, more investigations are devoted to improving the …

PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development

JG Lee, JM Yon, G Kim, SG Lee, CY Kim… - Nature …, 2024 - nature.com
Proper placental development in early pregnancy ensures a positive outcome later on. The
developmental relationship between the placenta and embryonic organs, such as the heart …

Effects of Prenatal Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, on Offspring's Health: Evidence from Epidemiological and Experimental Studies

R Algonaiman, AS Almutairi, MM Al Zhrani, H Barakat - Biomolecules, 2023 - mdpi.com
Pregnancy and lactation are critical periods for human well-being and are sensitive windows
for pollutant exposure. Bisphenol A (BPA) is well demonstrated as a toxicant and has been …

Epigenetic dynamics of partially methylated domains in human placenta and trophoblast stem cells

H Toh, H Okae, K Shirane, T Sato, H Hamada… - BMC genomics, 2024 - Springer
Background The placenta is essential for nutrient exchange and hormone production
between the mother and the develo** fetus and serves as an invaluable model for …