CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
Internal senses of the vagus nerve
The vagus nerve is an indispensable body-brain connection that controls vital aspects of
autonomic physiology like breathing, heart rate, blood pressure, and gut motility, reflexes …
autonomic physiology like breathing, heart rate, blood pressure, and gut motility, reflexes …
GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism
Summary Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin
action in obese rodents. Whether and how GDF15 improves insulin action without weight …
action in obese rodents. Whether and how GDF15 improves insulin action without weight …
The physiological control of eating: signals, neurons, and networks
AG Watts, SE Kanoski, G Sanchez-Watts… - Physiological …, 2022 - journals.physiology.org
During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …
Novel noninvasive approaches to the treatment of obesity: from pharmacotherapy to gene therapy
Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …
discovery of several promising drug targets and novel therapeutic strategies to address the …
The role of GDF15 as a myomitokine
Growth differentiation factor 15 (GDF15) is a cytokine best known for affecting systemic
energy metabolism through its anorectic action. GDF15 expression and secretion from …
energy metabolism through its anorectic action. GDF15 expression and secretion from …
[HTML][HTML] Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist
GDF15 and its receptor GFRAL/RET form a non-homeostatic system that regulates food
intake and body weight in preclinical species. Here, we describe a GDF15 analog …
intake and body weight in preclinical species. Here, we describe a GDF15 analog …
[HTML][HTML] Metformin triggers a kidney GDF15-dependent area postrema axis to regulate food intake and body weight
Metformin, the most widely prescribed medication for obesity-associated type 2 diabetes
(T2D), lowers plasma glucose levels, food intake, and body weight in rodents and humans …
(T2D), lowers plasma glucose levels, food intake, and body weight in rodents and humans …
Hindbrain circuits in the control of eating behaviour and energy balance
W Cheng, D Gordian, MQ Ludwig, TH Pers… - Nature …, 2022 - nature.com
Body weight and adiposity represent biologically controlled parameters that are influenced
by a combination of genetic, developmental and environmental variables. Although the …
by a combination of genetic, developmental and environmental variables. Although the …
Acts of appetite: neural circuits governing the appetitive, consummatory, and terminating phases of feeding
The overconsumption of highly caloric and palatable foods has caused a surge in obesity
rates in the past half century, thereby posing a healthcare challenge due to the array of …
rates in the past half century, thereby posing a healthcare challenge due to the array of …