Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

Cancer is a complex multistep process involving genetic and epigenetic changes that
eventually result in the activation of oncogenic pathways and/or inactivation of tumor …

MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of
cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly …

The epithelial to mesenchymal transition (EMT) is a powerful process in tumor invasion,
metastasis, and tumorigenesis and describes the molecular reprogramming and phenotypic …

Tumor metastases are responsible for approximately 90% of all cancer-related deaths.
Although many patients can be cured, in the US and UK, cancer still causes 730,000 deaths …

Raf are conserved, ubiquitous serine/protein kinases discovered as the cellular elements
hijacked by transforming retroviruses. The three mammalian RAF proteins (A, B and CRAF) …

We have previously described a small interfering RNA (siRNA) delivery system (AtuPLEX)
for RNA interference (RNAi) in the vasculature of mice. Here we report preclinical data for …

The development of metastasis requires the movement and invasion of cancer cells from the
primary tumor into the surrounding tissue. To acquire such invasive abilities, epithelial …

Background Lung cancer is the leading cause of cancer deaths worldwide. New diagnostics
are needed to detect early stage lung cancer because it may be cured with surgery …

In this study, we demonstrate that a small population of pluripotent stem cells, termed
adipose multilineage-differentiating stress-enduring (adipose-Muse) cells, exist in adult …