Therapeutic drug monitoring (TDM) is the quantification and interpretation of drug
concentrations in blood to optimize pharmacotherapy. It considers the interindividual …

Antipsychotic drugs are central to the treatment of schizophrenia and other psychotic
disorders but are ineffective for some patients and associated with side-effects and …

Therapeutic drug monitoring (TDM), ie, the quantification of serum or plasma concentrations
of medications for dose optimization, has proven a valuable tool for the patient-matched …

To develop a European guideline on pharmacologic treatment of Tourette syndrome (TS)
the available literature was thoroughly screened and extensively discussed by a working …

Dopamine partial agonism and functional selectivity have been innovative strategies in the
pharmacological treatment of schizophrenia and mood disorders and have shifted the …

Molecular imaging methods such as positron emission tomography (PET) are increasingly
involved in the development of new drugs. Using radioactive tracers as imaging probes, PET …

Rationale While one of the basic axioms of pharmacology postulates that there is a
relationship between the concentration and effects of a drug, the value of measuring blood …

Antipsychotic drugs were introduced in the early 50s on the basis of clinical observations in
patients with schizophrenia. Experimental studies later revealed that antagonism at the D2 …

Aripiprazole was the first antipsychotic developed to possess agonist properties at
dopamine D2 autoreceptors, a groundbreaking strategy that presented a new vista for …

Recent clinical trials have raised questions over the perceived advantages of second-
generation'atypical'antipsychotics over those from the first generation. An atypical …