GATA transcription factors in development and disease
M Tremblay, O Sanchez-Ferras, M Bouchard - Development, 2018 - journals.biologists.com
The GATA family of transcription factors is of crucial importance during embryonic
development, playing complex and widespread roles in cell fate decisions and tissue …
development, playing complex and widespread roles in cell fate decisions and tissue …
Haematopoietic and immune defects associated with GATA2 mutation
Heterozygous familial or sporadic GATA 2 mutations cause a multifaceted disorder,
encompassing susceptibility to infection, pulmonary dysfunction, autoimmunity …
encompassing susceptibility to infection, pulmonary dysfunction, autoimmunity …
Regulation of the HIF-1α level is essential for hematopoietic stem cells
Hematopoietic stem cells (HSCs) are sustained in a specific microenvironment known as the
stem cell niche. Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic zone …
stem cell niche. Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic zone …
Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators
Combinatorial transcription factor (TF) interactions control cellular phenotypes and,
therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the …
therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the …
DNA methylation dynamics during in vivo differentiation of blood and skin stem cells
DNA methylation is a mechanism of epigenetic regulation that is common to all vertebrates.
Functional studies underscore its relevance for tissue homeostasis, but the global dynamics …
Functional studies underscore its relevance for tissue homeostasis, but the global dynamics …
Characterization of transcriptional networks in blood stem and progenitor cells using high-throughput single-cell gene expression analysis
V Moignard, IC Macaulay, G Swiers, F Buettner… - Nature cell …, 2013 - nature.com
Cellular decision-making is mediated by a complex interplay of external stimuli with the
intracellular environment, in particular transcription factor regulatory networks. Here we have …
intracellular environment, in particular transcription factor regulatory networks. Here we have …
The analysis, roles and regulation of quiescence in hematopoietic stem cells
A Nakamura-Ishizu, H Takizawa, T Suda - Development, 2014 - journals.biologists.com
Tissue homeostasis requires the presence of multipotent adult stem cells that are capable of
efficient self-renewal and differentiation; some of these have been shown to exist in a …
efficient self-renewal and differentiation; some of these have been shown to exist in a …
[HTML][HTML] Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity
KD Johnson, AP Hsu, MJ Ryu, J Wang… - The Journal of …, 2012 - Am Soc Clin Investig
The transcription factor GATA-2 plays vital roles in quite diverse developmental programs,
including hematopoietic stem cell (HSC) survival and proliferation. We previously identified …
including hematopoietic stem cell (HSC) survival and proliferation. We previously identified …
Gata2 as a crucial regulator of stem cells in adult hematopoiesis and acute myeloid leukemia
JB Menendez-Gonzalez, M Vukovic, A Abdelfattah… - Stem cell reports, 2019 - cell.com
Subversion of transcription factor (TF) activity in hematopoietic stem/progenitor cells
(HSPCs) leads to the development of therapy-resistant leukemic stem cells (LSCs) that drive …
(HSPCs) leads to the development of therapy-resistant leukemic stem cells (LSCs) that drive …
The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal
The histone acetyltransferase HBO1 (MYST2, KAT7) is indispensable for postgastrulation
development, histone H3 lysine 14 acetylation (H3K14Ac), and the expression of embryonic …
development, histone H3 lysine 14 acetylation (H3K14Ac), and the expression of embryonic …