The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

Animals live in habitats fraught with a range of environmental challenges to their bodies and
brains. Accordingly, cells and organ systems have evolved stress-responsive signaling …

Background Inflammation contributes to the poor prognosis of intracerebral hemorrhage
(ICH). Intermittent fasting (IF) has been shown to be protective against inflammation in …

Overnutrition is a risk factor for various human diseases, including neurodegenerative
diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a …

Aging is the major risk factor for neurodegenerative diseases, accelerated by excessive
calorie consumption and sedentary lifestyles. Bioenergetic challenges such as intermittent …

Mitochondria are thought to have become incorporated within the eukaryotic cell
approximately 2 billion years ago and play a role in a variety of cellular processes, such as …

Alzheimer's disease (AD) is the most common form of dementia without effective clinical
treatment. Here, we show that intermittent fasting (IF) improves cognitive functions and AD …

Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …

Background: Weight loss by lifestyle modification is the cornerstone therapy of non-alcoholic
fatty liver disease (NAFLD). Intermittent fasting has shown favorable effects on body weight …

The protein Klotho can significantly delay aging, so it has attracted widespread attention.
Abnormal downregulation of Klotho has been detected in several aging-related diseases …