The SARS-CoV-2 nucleocapsid protein and its role in viral structure, biological functions, and a potential target for drug or vaccine mitigation

Z Bai, Y Cao, W Liu, J Li - Viruses, 2021 - mdpi.com
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the world
is still expanding. Thus, there is an urgent need to better understand this novel virus and find …

Roles of flavonoids against coronavirus infection

M Russo, S Moccia, C Spagnuolo, I Tedesco… - Chemico-biological …, 2020 - Elsevier
In terms of public health, the 21st century has been characterized by coronavirus
pandemics: in 2002-03 the virus SARS-CoV caused SARS; in 2012 MERS-CoV emerged …

Drug targets for corona virus: A systematic review

M Prajapat, P Sarma, N Shekhar, P Avti… - Indian journal of …, 2020 - journals.lww.com
Abstract The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21 th
century. However, the lack of specific drugs to prevent/treat an attack is a major need at this …

Antiviral activity of green tea and black tea polyphenols in prophylaxis and treatment of COVID-19: A review

S Mhatre, T Srivastava, S Naik, V Patravale - Phytomedicine, 2021 - Elsevier
Background The rapid spread of novel coronavirus called SARS-CoV-2 or nCoV has caused
countries all over the world to impose lockdowns and undertake stringent preventive …

Natural products and their derivatives against coronavirus: A review of the non‐clinical and pre‐clinical data

MT Islam, C Sarkar, DM El‐Kersh… - Phytotherapy …, 2020 - Wiley Online Library
Several corona viral infections have created serious threats in the last couple of decades
claiming the death of thousands of human beings. Recently, corona viral epidemic raised …

Promising antiviral activities of natural flavonoids against SARS-CoV-2 targets: systematic review

R Kaul, P Paul, S Kumar, D Büsselberg… - International journal of …, 2021 - mdpi.com
The ongoing COVID-19 pandemic, caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) became a globally leading public health concern over the past …

GCG inhibits SARS-CoV-2 replication by disrupting the liquid phase condensation of its nucleocapsid protein

M Zhao, Y Yu, LM Sun, JQ **ng, T Li, Y Zhu… - Nature …, 2021 - nature.com
Lack of detailed knowledge of SARS-CoV-2 infection has been hampering the development
of treatments for coronavirus disease 2019 (COVID-19). Here, we report that RNA triggers …

[HTML][HTML] Potentials of plant-based substance to inhabit and probable cure for the COVID-19

I Jahan, O Ahmet - Turkish Journal of Biology, 2020 - ncbi.nlm.nih.gov
COVID-19 has been the most devastating pandemic in human history. Despite the highest
scientific efforts and investments, a reliable and certified medication has yet to be developed …

[HTML][HTML] SARS-CoV-2 pathophysiology and assessment of coronaviruses in CNS diseases with a focus on therapeutic targets

J Vallamkondu, A John, WY Wani, SP Ramadevi… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The novel Coronavirus disease of 2019 (nCOV-19) is a viral outbreak noted first in Wuhan,
China. This disease is caused by Severe Acute Respiratory Syndrome (SARS) Coronavirus …

[HTML][HTML] Withania somnifera (L.) Dunal: opportunity for clinical repurposing in COVID-19 management

A Saggam, K Limgaokar, S Borse… - Frontiers in …, 2021 - frontiersin.org
As the COVID-19 pandemic is progressing, the therapeutic gaps in conventional
management have highlighted the need for the integration of traditional knowledge systems …