The emerging complexity of the transcriptional landscape poses great challenges to our
conventional preconceptions of how the genome regulates brain function and dysfunction …

It is well known that only a small proportion of the human genome code for proteins; the rest
belong to the family of RNAs that do not code for protein and are known as non-coding …

Neuronal alternative splicing is a key gene regulatory mechanism in the brain. However, the
spliceosome machinery is insufficient to fully specify splicing complexity. In considering the …

Small non-coding RNAs (sncRNAs) make up~ 1% of the transcriptome; nevertheless, they
play significant roles in regulating cellular processes. Given the complexity of the central …

RNA sequencing analyses are often limited to identifying lowest p value transcripts, which
does not address polygenic phenomena. To overcome this limitation, we developed an …

The vast use of corticosteroids (CCSs) globally has led to an increase in CCS-induced
neuropsychiatric disorders (NPDs), a very common manifestation in patients after CCS …

Delineating the pathophysiology of psychiatric disorders has been extremely challenging
but technological advances in recent decades have facilitated a deeper interrogation of …

Abstract Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative
disorder in the elderly. The development and progression of DLB remain unclear. In this …

Dementia with Lewy bodies and Parkinson's disease dementia are common
neurodegenerative diseases that share similar neuropathological profiles and spectra of …

Advances in genomic medicine have the potential to change the way we treat human
disease, but translating these advances into reality for improving healthcare outcomes …