Genomics, convergent neuroscience and progress in understanding autism spectrum disorder
More than a hundred genes have been identified that, when disrupted, impart large risk for
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …
Human brain organogenesis: Toward a cellular understanding of development and disease
The construction of the human nervous system is a distinctly complex although highly
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
regulated process. Human tissue inaccessibility has impeded a molecular understanding of …
[HTML][HTML] Brain charts for the human lifespan
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research
and clinical studies of the human brain. However, no reference standards currently exist to …
and clinical studies of the human brain. However, no reference standards currently exist to …
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders
To date, most expression quantitative trait loci (eQTL) studies, which investigate how genetic
variants contribute to gene expression, have been performed in heterogeneous brain …
variants contribute to gene expression, have been performed in heterogeneous brain …
Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of
primates that is centrally involved in cognition. We assessed more than 600,000 single …
primates that is centrally involved in cognition. We assessed more than 600,000 single …
De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome
Around 60% of individuals with neurodevelopmental disorders (NDD) remain undiagnosed
after comprehensive genetic testing, primarily of protein-coding genes. Large genome …
after comprehensive genetic testing, primarily of protein-coding genes. Large genome …
Map** gene transcription and neurocognition across human neocortex
Regulation of gene expression drives protein interactions that govern synaptic wiring and
neuronal activity. The resulting coordinated activity among neuronal populations supports …
neuronal activity. The resulting coordinated activity among neuronal populations supports …
Autism spectrum disorder genetics and the search for pathological mechanisms
Recent progress in the identification of genes and genomic regions contributing to autism
spectrum disorder (ASD) has had a broad impact on our understanding of the nature of …
spectrum disorder (ASD) has had a broad impact on our understanding of the nature of …
Brain-based sex differences in autism spectrum disorder across the lifespan: A systematic review of structural MRI, fMRI, and DTI findings
Females with autism spectrum disorder (ASD) have been long overlooked in neuroscience
research, but emerging evidence suggests they show distinct phenotypic trajectories and …
research, but emerging evidence suggests they show distinct phenotypic trajectories and …