The aetiology and pathophysiology of complex diseases are driven by the interaction
between genetic and environmental factors. The variability in risk and outcomes in these …

Childhood maltreatment is a major risk factor for chronic and severe mental and physical
health problems across the lifespan. Increasing evidence supports the hypothesis that …

Race and Genetic Ancestry in Medicine US health inequities won't be eliminated by
abandoning the use of race and ethnicity in research and clinical practice, since these …

DNA methylation microarrays can be employed to interrogate cell-type composition in
complex tissues. Here, we expand reference-based deconvolution of blood DNA …

Background This study investigates the associations between air pollution and colorectal
cancer (CRC) risk and survival from an epigenomic perspective. Methods Using a newly …

Overlap** clinical phenotypes and an expanding breadth and complexity of genomic
associations are a growing challenge in the diagnosis and clinical management of …

Abstract Purpose of Review Using the WHO Conceptual Framework for Action on the Social
Determinants of Health, this review provides a discussion of recent epidemiologic …

Pathogen-imposed selection pressures have been paramount during human evolution.
Detecting such selection signatures in ancient and modern human genomes can thus help …

DNA methylation is an ideal trait to study the extent of the shared genetic control across
ancestries, effectively providing hundreds of thousands of model molecular traits with large …

Behavioral genetics and cultural evolution have both revolutionized our understanding of
human behavior–largely independent of each other. Here, we reconcile these two fields …