C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at
sites of infection or inflammation. CRP is produced as a homopentameric protein, termed …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Myocardial necrosis triggers an inflammatory reaction that clears the wound from dead cells
and matrix debris, while activating reparative pathways necessary for scar formation. A …

Heart failure is considered an epidemic disease in the modern world affecting approximately
1% to 2% of adult population. It presents a multifactorial, systemic disease, in which—after …

Background Sepsis is characterised by dysregulated, life-threatening immune responses,
which are thought to be driven by cytokines such as interleukin 6 (IL-6). Genetic variants in …

Importance Surgeons make complex, high-stakes decisions under time constraints and
uncertainty, with significant effect on patient outcomes. This review describes the …

HDL lowers the risk for atherosclerotic cardiovascular disease by promoting cholesterol
efflux from macrophage foam cells. However, other antiatherosclerotic properties of HDL are …

Inflammation has been recognized as a major pathophysiological contributor to the entire
spectrum of human heart failure (HF), including HF with reduced ejection fraction, HF with …

Bioelectronic transducing surfaces that are nanometric in size have been the main route to
detect single molecules. Though enabling the study of rarer events, such methodologies are …

Acute myocardial infarction is a severe ischemic disease responsible for heart failure and
sudden death. Here, we show that after acute myocardial infarction in mice, mature B …