Signal pathways of melanoma and targeted therapy
W Guo, H Wang, C Li - Signal transduction and targeted therapy, 2021 - nature.com
Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …
Principles and challenges of genome-wide DNA methylation analysis
PW Laird - Nature Reviews Genetics, 2010 - nature.com
Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …
eukaryotes that has important implications for normal biology and disease. Therefore …
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
We characterized the mutational landscape of melanoma, the form of skin cancer with the
highest mortality rate, by sequencing the exomes of 147 melanomas. Sun-exposed …
highest mortality rate, by sequencing the exomes of 147 melanomas. Sun-exposed …
SWAN: Subset-quantile within array normalization for illumina infinium HumanMethylation450 BeadChips
DNA methylation is the most widely studied epigenetic mark and is known to be essential to
normal development and frequently disrupted in disease. The Illumina …
normal development and frequently disrupted in disease. The Illumina …
Epigenetic regulation in human melanoma: past and future
The development and progression of melanoma have been attributed to independent or
combined genetic and epigenetic events. There has been remarkable progress in …
combined genetic and epigenetic events. There has been remarkable progress in …
Aberrant DNA methylation in melanoma: biomarker and therapeutic opportunities
G Micevic, N Theodosakis, M Bosenberg - Clinical epigenetics, 2017 - Springer
Aberrant DNA methylation is an epigenetic hallmark of melanoma, known to play important
roles in melanoma formation and progression. Recent advances in genome-wide …
roles in melanoma formation and progression. Recent advances in genome-wide …
Copy number analysis of whole-genome data using BIC-seq2 and its application to detection of cancer susceptibility variants
Whole-genome sequencing data allow detection of copy number variation (CNV) at high
resolution. However, estimation based on read coverage along the genome suffers from …
resolution. However, estimation based on read coverage along the genome suffers from …
[HTML][HTML] A subset of methylated CpG sites differentiate psoriatic from normal skin
Psoriasis is a chronic inflammatory immune-mediated disorder affecting the skin and other
organs including joints. Over 1,300 transcripts are altered in psoriatic involved skin …
organs including joints. Over 1,300 transcripts are altered in psoriatic involved skin …
Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia
The epigenetic impact of DNA methylation in chronic myelogenous leukemia (CML) is not
completely understood. To elucidate its role we analyzed 120 patients with CML for …
completely understood. To elucidate its role we analyzed 120 patients with CML for …
An atlas of DNA methylomes in porcine adipose and muscle tissues
It is evident that epigenetic factors, especially DNA methylation, have essential roles in
obesity development. Here, using pig as a model, we investigate the systematic association …
obesity development. Here, using pig as a model, we investigate the systematic association …