Chronic obstructive pulmonary disease biomarkers and their interpretation

RA Stockley, DMG Halpin, BR Celli… - American journal of …, 2019 - atsjournals.org
The pathology and impact of chronic obstructive pulmonary disease (COPD) results from an
abnormal inflammatory process resulting in tissue damage with ineffective repair in …

[HTML][HTML] Chemokines in COPD: from implication to therapeutic use

P Henrot, R Prevel, P Berger, I Dupin - International journal of molecular …, 2019 - mdpi.com
Chronic Obstructive Pulmonary Disease (COPD) represents the 3rd leading cause of death
in the world. The underlying pathophysiological mechanisms have been the focus of …

Comparison of proteomic assessment methods in multiple cohort studies

LM Raffield, H Dang, KA Pratte, S Jacobson… - …, 2020 - Wiley Online Library
Novel proteomics platforms, such as the aptamer‐based SOMAscan platform, can quantify
large numbers of proteins efficiently and cost‐effectively and are rapidly growing in …

The role of IL-33/ST2 in COPD and its future as an antibody therapy

L Riera-Martínez, L Cànaves-Gómez, A Iglesias… - International journal of …, 2023 - mdpi.com
COPD is a leading cause of mortality and morbidity worldwide and is associated with a high
socioeconomic burden. Current treatment includes the use of inhaled corticosteroids and …

[HTML][HTML] Molecular characteristics and treatment of endothelial dysfunction in patients with COPD: a review article

B Szucs, C Szucs, M Petrekanits, JT Varga - International journal of …, 2019 - mdpi.com
Patients with chronic obstructive pulmonary disease (COPD) show systemic consequences,
such as chronic systemic inflammation leading to changes in the airway, airway …

Biomarkers of exposure and effect in the lungs of smokers, nonsmokers, and electronic cigarette users

MA Song, JL Freudenheim, TM Brasky… - Cancer Epidemiology …, 2020 - aacrjournals.org
Background: Nicotine-containing electronic cigarette (e-cig) use has become widespread.
However, understanding the biological impact of e-cigs compared with smoking on the lung …

Protein biomarkers for COPD outcomes

KA Serban, KA Pratte, RP Bowler - Chest, 2021 - Elsevier
COPD is a clinically heterogeneous syndrome characterized by injury to airways, airspaces,
and lung vasculature and usually caused by tobacco smoke and/or air pollution exposure …

Omics and the search for blood biomarkers in chronic obstructive pulmonary disease. Insights from COPDGene

EA Regan, CP Hersh, PJ Castaldi… - American journal of …, 2019 - atsjournals.org
There is an unmet need for blood biomarkers in diagnosis and prognosis of chronic
obstructive pulmonary disease (COPD). The search for these biomarkers has been …

Schisandrin A regulates the Nrf2 signaling pathway and inhibits NLRP3 inflammasome activation to interfere with pyroptosis in a mouse model of COPD

J Zeng, S Liao, Z Liang, C Li, Y Luo, K Wang… - European Journal of …, 2023 - Springer
Chronic obstructive pulmonary disease (COPD) is a serious chronic lung disease.
Schisandrin A (SchA) is one of the most important active ingredients in Schisandra chinensis …

Deep learning on graphs for multi-omics classification of COPD

Y Zhuang, F **ng, D Ghosh, BD Hobbs, CP Hersh… - Plos one, 2023 - journals.plos.org
Network approaches have successfully been used to help reveal complex mechanisms of
diseases including Chronic Obstructive Pulmonary Disease (COPD). However despite …