The hypothalamic-pituitary-adrenal (HPA) axis is involved in the pathophysiology of many
neuropsychiatric disorders. Increased HPA axis activity can be observed during chronic …

Cortisol—the most important steroid hormone with a significant effect on body metabolism—
strongly affects peripheral tissues and the central nervous system. Fluctuations in cortisol …

Abstract Purpose of Review We review recent developments on risk factors in
schizophrenia. Recent Findings The way we think about schizophrenia today is profoundly …

Schizophrenia is a disorder with a heterogeneous etiology involving complex interplay
between genetic and environmental risk factors. The immune system is now known to play …

Over the past decade, our understanding of the role of stress in serious mental illness has
become more sophisticated. In this paper, we revisit the neural diathesis-stress model of …

Objective: Using longitudinal and prospective measures of trauma during childhood, the
authors assessed the risk of develo** psychotic symptoms associated with maltreatment …

OBJECTIVE: People with schizophrenia show a high incidence of metabolic syndrome,
which is associated with a high mortality from cardiovascular disease. The aetiology of the …

Introduction: Recent models of psychosis implicate stressful events in its etiology. However,
while evidence has accumulated for childhood trauma, the role of adult life events has …

There is a substantial body of research reporting evidence of associations between various
forms of childhood adversity and psychosis, across the spectrum from experiences to …

Background: Cortisol and inflammatory markers have been increasingly reported as
abnormal at psychosis onset. The main aim of our study was to investigate the ability of …