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A guide to studying protein aggregation
Disrupted protein folding or decreased protein stability can lead to the accumulation of
(partially) un‐or misfolded proteins, which ultimately cause the formation of protein …
(partially) un‐or misfolded proteins, which ultimately cause the formation of protein …
Theory and applications of differential scanning fluorimetry in early-stage drug discovery
K Gao, R Oerlemans, MR Groves - Biophysical reviews, 2020 - Springer
Differential scanning fluorimetry (DSF) is an accessible, rapid, and economical biophysical
technique that has seen many applications over the years, ranging from protein folding state …
technique that has seen many applications over the years, ranging from protein folding state …
Rapid alkalinization factor 22 has a structural and signalling role in root hair cell wall assembly
Pressurized cells with strong walls make up the hydrostatic skeleton of plants. Assembly and
expansion of such stressed walls depend on a family of secreted RAPID ALKALINIZATION …
expansion of such stressed walls depend on a family of secreted RAPID ALKALINIZATION …
Plant cell wall patterning and expansion mediated by protein-peptide-polysaccharide interaction
Assembly of cell wall polysaccharides into specific patterns is required for plant growth. A
complex of RAPID ALKALINIZATION FACTOR 4 (RALF4) and its cell wall–anchored …
complex of RAPID ALKALINIZATION FACTOR 4 (RALF4) and its cell wall–anchored …
Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …
Chemically stable fluorescent proteins for advanced microscopy
We report the rational engineering of a remarkably stable yellow fluorescent protein
(YFP),'hyperfolder YFP'(hfYFP), that withstands chaotropic conditions that denature most …
(YFP),'hyperfolder YFP'(hfYFP), that withstands chaotropic conditions that denature most …
Small-molecule inhibitors of the coronavirus spike: ACE2 protein–protein interaction as blockers of viral attachment and entry for SARS-CoV-2
D Bojadzic, O Alcazar, J Chen, ST Chuang… - ACS infectious …, 2021 - ACS Publications
Inhibitors of the protein–protein interaction (PPI) between the SARS-CoV-2 spike protein
and human ACE2 (hACE2), which acts as a ligand–receptor pair that initiates the viral …
and human ACE2 (hACE2), which acts as a ligand–receptor pair that initiates the viral …
Epigallocatechin-3-gallate, an active ingredient of Traditional Chinese Medicines, inhibits the 3CLpro activity of SARS-CoV-2
A Du, R Zheng, C Disoma, S Li, Z Chen, S Li… - International journal of …, 2021 - Elsevier
SARS-CoV-2 is the etiological agent responsible for the ongoing pandemic of coronavirus
disease 2019 (COVID-19). The main protease of SARS-CoV-2, 3CLpro, is an attractive …
disease 2019 (COVID-19). The main protease of SARS-CoV-2, 3CLpro, is an attractive …
Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2
Abstract SARS-CoV-2 Nsp15 is a uridine-specific endoribonuclease with C-terminal catalytic
domain belonging to the EndoU family that is highly conserved in coronaviruses. As …
domain belonging to the EndoU family that is highly conserved in coronaviruses. As …
Counteraction of stability-activity trade-off of Nattokinase through flexible region shifting
J Luo, C Song, W Cui, L Han, Z Zhou - Food Chemistry, 2023 - Elsevier
The widespread trade-off between stability and activity severely limits enzyme evolution.
Although some progresses have been made to overcome this limitation, the counteraction …
Although some progresses have been made to overcome this limitation, the counteraction …