During the past decades, better understanding of relapsing-remitting multiple sclerosis
disease mechanisms have led to the development of several disease-modifying therapies …

There is a broad consensus that multiple sclerosis (MS) represents more than an
inflammatory disease: it harbors several characteristic aspects of a classical …

Background Interferon beta is used to modify the course of relapsing multiple sclerosis.
Despite interferon beta therapy, many patients have relapses. Natalizumab, an α4 integrin …

Objective: The study was undertaken to determine the pathologic basis of subtle
abnormalities in magnetization transfer ratio (MTR) and diffusion tensor imaging (DTI) …

The pathophysiology of multiple sclerosis (MS) is characterized by demyelination, which
culminates in a reduction in axonal transmission. Axonal and neuronal degeneration seem …

Axonal and neuronal degeneration are important features of multiple sclerosis (MS) and
other neurologic disorders that affect the anterior visual pathway. Optical coherence …

Objective: To conduct systematic long-term follow-up (LTFU) of patients in the Prevention of
Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis …

The classical view of MS as a chronic inflammatory demyelinating disease leading to the
formation of focal central nervous system (CNS) white matter (WM) lesions has been …

BACKGROUND AND PURPOSE: Inhomogeneous magnetization transfer is a new
endogenous MR imaging contrast mechanism that has demonstrated high specificity for …

Myelin-sensitive MRI such as magnetization transfer imaging has been widely used in
multiple sclerosis. The influence of methodology and differences in disease subtype on …