Designing nanozymes for in vivo applications

R Zhang, B Jiang, K Fan, L Gao, X Yan - Nature Reviews …, 2024 - nature.com
Biocatalytic drugs, including natural and artificial enzymes that can accelerate biochemical
reactions, are promising tools to address redox imbalances, metabolic disorders and …

[HTML][HTML] Enzyme therapy: current challenges and future perspectives

M De La Fuente, L Lombardero… - International Journal of …, 2021 - mdpi.com
In recent years, enzymes have risen as promising therapeutic tools for different pathologies,
from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint …

Multimodal enzyme delivery and therapy enabled by cell membrane-coated metal–organic framework nanoparticles

J Zhuang, Y Duan, Q Zhang, W Gao, S Li, RH Fang… - Nano …, 2020 - ACS Publications
Therapeutic enzymes used for genetic disorders or metabolic diseases oftentimes suffer
from suboptimal pharmacokinetics and stability. Nanodelivery systems have shown …

A dual functional nanoreactor for synergistic starvation and photodynamic therapy

Y Zhu, H Shi, T Li, J Yu, Z Guo, J Cheng… - ACS applied materials & …, 2020 - ACS Publications
The combination of photodynamic therapy (PDT) and enzyme therapy is a highly desirable
approach in malignant tumor therapies as it takes advantage of the spatial-controlled PDT …

Isolation and characterization of Lactobacillus-derived membrane vesicles

SN Dean, DH Leary, CJ Sullivan, E Oh, SA Walper - Scientific reports, 2019 - nature.com
Bacterial membrane vesicles have been implicated in a broad range of functions in
microbial communities from pathogenesis to gene transfer. Though first thought to be a …

Lactobacillus acidophilus Membrane Vesicles as a Vehicle of Bacteriocin Delivery

SN Dean, MA Rimmer, KB Turner, DA Phillips… - Frontiers in …, 2020 - frontiersin.org
Recent reports have shown that Gram-positive bacteria actively secrete spherical nanometer-
sized proteoliposome membrane vesicles (MVs) into their surroundings. Though MVs are …

Enzymatic bioremediation of organophosphate compounds—progress and remaining challenges

M Thakur, IL Medintz, SA Walper - Frontiers in bioengineering and …, 2019 - frontiersin.org
Organophosphate compounds are ubiquitously employed as agricultural pesticides and
maintained as chemical warfare agents by several nations. These compounds are highly …

Antineoplastic enzyme as drug carrier with activatable catalytic activity for efficient combined therapy

Y Zhang, S Jiang, J Lin, P Huang - … Chemie International Edition, 2022 - Wiley Online Library
The delivery of glucose oxidase (GOx) requires extra carriers, which suffers from early
leakage and exposure of GOx. These issues will be of less concern if GOx itself acts as a …

Enhancing the therapeutic use of biofilm-dispersing enzymes with smart drug delivery systems

CR Thorn, PL Howell, DJ Wozniak, CA Prestidge… - Advanced Drug Delivery …, 2021 - Elsevier
Biofilm-dispersing enzymes degrade the extracellular polymeric matrix surrounding bacterial
biofilms, disperse the microbial community and increase their susceptibility to antibiotics and …

[HTML][HTML] Microbial therapeutic enzymes: A promising area of biopharmaceuticals

M Vachher, A Sen, R Kapila, A Nigam - Current research in biotechnology, 2021 - Elsevier
Biopharmaceuticals is a rapidly emerging field that explores and employs biological
organisms and their products for therapeutic applications. Enzymes are remarkable …