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Nitric oxide signalling in cardiovascular health and disease
Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …
Congenital long QT syndrome
Congenital long QT syndrome (LQTS) encompasses a group of heritable conditions that are
associated with cardiac repolarization dysfunction. Since its initial description in 1957, our …
associated with cardiac repolarization dysfunction. Since its initial description in 1957, our …
[HTML][HTML] hERG K+ channels: structure, function, and clinical significance
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …
Epidemiology and genetics of sudden cardiac death
Sudden cardiac death (SCD) generally refers to an unexpected death from a cardiovascular
cause in a person with or without preexisting heart disease. The specificity of this definition …
cause in a person with or without preexisting heart disease. The specificity of this definition …
Personalizing risk stratification for sudden death in dilated cardiomyopathy: the past, present, and future
Results from the DANISH Study (Danish Study to Assess the Efficacy of ICDs in Patients
With Non-Ischemic Systolic Heat Failure on Mortality) suggest that for many patients with …
With Non-Ischemic Systolic Heat Failure on Mortality) suggest that for many patients with …
The measurement of the QT interval
PG Postema, A AM Wilde - Current cardiology reviews, 2014 - ingentaconnect.com
The evaluation of every electrocardiogram should also include an effort to interpret the QT
interval to assess the risk of malignant arrhythmias and sudden death associated with an …
interval to assess the risk of malignant arrhythmias and sudden death associated with an …
Genetics of sudden cardiac death
Sudden cardiac death occurs in a broad spectrum of cardiac pathologies and is an important
cause of mortality in the general population. Genetic studies conducted during the past 20 …
cause of mortality in the general population. Genetic studies conducted during the past 20 …
Transethnic genome-wide association study provides insights in the genetic architecture and heritability of long QT syndrome
Background: Long QT syndrome (LQTS) is a rare genetic disorder and a major preventable
cause of sudden cardiac death in the young. A causal rare genetic variant with large effect …
cause of sudden cardiac death in the young. A causal rare genetic variant with large effect …
Exome‐based analysis of cardiac arrhythmia, respiratory control, and epilepsy genes in sudden unexpected death in epilepsy
Objective The leading cause of epilepsy‐related premature mortality is sudden unexpected
death in epilepsy (SUDEP). The cause of SUDEP remains unknown. To search for genetic …
death in epilepsy (SUDEP). The cause of SUDEP remains unknown. To search for genetic …
Long-QT syndrome: from genetics to management
Schwartz et al LQTS: From Genetics to Management 869 transmembrane portion of the K+
channel with a mild dominant-negative functional effect; in these patients, we demonstrated …
channel with a mild dominant-negative functional effect; in these patients, we demonstrated …