The cosolvency models frequently used in solubility data modeling of drugs in mixed
solvents were reviewed and their accuracies for calculating the solubility of solutes were …

The solubility of a solute is an important physico-chemical property of drugs/chemicals and
is highly in demand in the industry. Addition of the second solvent is a common procedure to …

Aqueous solubility is one of the major challenges in the early stages of drug discovery. One
of the most common and effective methods for enhancing solubility is the addition of an …

A relatively simple two-body and three-body interactional mixing model is used to derive
expressions for the mathematical representation of experimental solute solubilities and …

It has been shown that the two theoretical cosolvency models, ie the excess free energy,
EFE, and the combined nearly ideal binary solvent/Redlich-Kister, CNIBS/RK, despite …

A new method for obtaining the model constants of the combined nearly ideal binary
solvent/Redlich-Kister (CNIBS/RK) equation, via least square analysis has been presented …

Applicability of a solution model for calculating solubility of amino acids in binary aqueous-
organic solvent mixtures at various temperatures was shown. The accuracy of the proposed …

The mole fraction solubility data of l-proline in five monosolvents (water, methanol, ethanol,
acetone, and acetonitrile) and four binary solvent systems (methanol+ acetone, ethanol+ …

Risperidone is one of the second-generation anti-schizophrenia representative drugs, which
is widely used in the treatment of acute and chronic schizophrenia. In this work, the solubility …

The solubility of l-phenylalanine in water and binary mixtures (methanol+ water and
ethanol+ water) at temperatures ranging from 288.15 to 318.15 K was investigated. The …