Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

The current opioid epidemic is one of the most severe public health crisis in US history.
Responding to it has been difficult due to its rapidly changing nature and the severity of its …

Importance No US national data are available on the prevalence and correlates ofDSM-5–
defined major depressive disorder (MDD) or on MDD specifiers as defined inDSM-5 …

We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …

Opioid-related overdose deaths have increased since 2010 in the US, but information on
trends in opioid use disorder (OUD) prevalence is limited due to unreliable data. Multiplier …

Importance Lack of current and comprehensive trend data derived from a uniform, reliable,
and valid source on alcohol use, high-risk drinking, andDSM-IValcohol use disorder (AUD) …

The prevalence of SUDs is increasing in the US general population, but these disorders
remain seriously undertreated. Stigma can reduce willingness of policymakers to allocate …

Objective To examine the associations between stop** treatment with opioids, length of
treatment, and death from overdose or suicide in the Veterans Health Administration. Design …

Importance Over the last 25 years, illicit cannabis use and cannabis use disorders have
increased among US adults, and 28 states have passed medical marijuana laws (MML) …

Background Opioid-related deaths have risen dramatically in rural communities. Prior
studies highlight few medication treatment providers for opioid use disorder in rural …