ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies
Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …
Apolipoprotein E and Alzheimer's disease: findings, hypotheses, and potential mechanisms
N Koutsodendris, MR Nelson, A Rao… - Annual Review of …, 2022 - annualreviews.org
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves
dysregulation of many cellular and molecular processes. It is notoriously difficult to develop …
dysregulation of many cellular and molecular processes. It is notoriously difficult to develop …
[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits
Abstract Apolipoprotein E4 (APOE4) is the strongest known genetic risk factor for late-onset
Alzheimer's disease (AD). Conditions of stress or injury induce APOE expression within …
Alzheimer's disease (AD). Conditions of stress or injury induce APOE expression within …
Imaging the evolution and pathophysiology of Alzheimer disease
W Jagust - Nature Reviews Neuroscience, 2018 - nature.com
Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …
studies of the relationships between the two major proteins deposited in this disease …
Causal machine learning for healthcare and precision medicine
Causal machine learning (CML) has experienced increasing popularity in healthcare.
Beyond the inherent capabilities of adding domain knowledge into learning systems, CML …
Beyond the inherent capabilities of adding domain knowledge into learning systems, CML …
Microglia in Alzheimer's disease: Pathogenesis, mechanisms, and therapeutic potentials
J Miao, H Ma, Y Yang, Y Liao, C Lin, J Zheng… - Frontiers in aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by protein
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …
aggregation in the brain. Recent studies have revealed the critical role of microglia in AD …
Challenges and opportunities with causal discovery algorithms: application to Alzheimer's pathophysiology
Abstract Causal Structure Discovery (CSD) is the problem of identifying causal relationships
from large quantities of data through computational methods. With the limited ability of …
from large quantities of data through computational methods. With the limited ability of …
Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer's disease
Background To assess the effects of apolipoprotein E (ApoE) ε4 genotype on amyloid-β (Aβ)
and tau burden and their longitudinal changes in Alzheimer's disease (AD) spectrum …
and tau burden and their longitudinal changes in Alzheimer's disease (AD) spectrum …