New views on PII signaling: from nitrogen sensing to global metabolic control

K Forchhammer, KA Selim, LF Huergo - Trends in Microbiology, 2022 - cell.com
PII proteins are multitasking information-processing proteins occurring in bacteria, archaea,
and plastids, decoding the metabolic state of the cells and providing this information to …

Carbon/nitrogen homeostasis control in cyanobacteria

K Forchhammer, KA Selim - FEMS microbiology reviews, 2020 - academic.oup.com
ABSTRACT Carbon/nitrogen (C/N) balance sensing is a key requirement for the
maintenance of cellular homeostasis. Therefore, cyanobacteria have evolved a …

The emergence of 2-oxoglutarate as a master regulator metabolite

LF Huergo, R Dixon - Microbiology and Molecular Biology …, 2015 - Am Soc Microbiol
The metabolite 2-oxoglutarate (also known as α-ketoglutarate, 2-ketoglutaric acid, or
oxoglutaric acid) lies at the intersection between the carbon and nitrogen metabolic …

Carbon/nitrogen metabolic balance: lessons from cyanobacteria

CC Zhang, CZ Zhou, RL Burnap, L Peng - Trends in Plant Science, 2018 - cell.com
Carbon and nitrogen are the two most abundant nutrient elements for all living organisms,
and their metabolism is tightly coupled. What are the signaling mechanisms that cells use to …

The novel PII-interactor PirC identifies phosphoglycerate mutase as key control point of carbon storage metabolism in cyanobacteria

T Orthwein, J Scholl, P Spät, S Lucius… - Proceedings of the …, 2021 - National Acad Sciences
Nitrogen limitation imposes a major transition in the lifestyle of nondiazotrophic
cyanobacteria that is controlled by a complex interplay of regulatory factors involving the …

PII signal transduction proteins: nitrogen regulation and beyond

LF Huergo, G Chandra, M Merrick - FEMS microbiology reviews, 2013 - academic.oup.com
The PII proteins are one of the most widely distributed families of signal transduction
proteins in nature. They are pivotal players in the control of nitrogen metabolism in bacteria …

Nitrogen metabolism in cyanobacteria: metabolic and molecular control, growth consequences and biotechnological applications

AA Esteves-Ferreira, M Inaba, A Fort… - Critical reviews in …, 2018 - Taylor & Francis
Cyanobacteria are one of the earliest branching groups of organisms on the planet, and
during their evolutionary history were submitted to varying selective pressures. Nowadays …

A widespread glutamine-sensing mechanism in the plant kingdom

VR Chellamuthu, E Ermilova, T Lapina, J Lüddecke… - Cell, 2014 - cell.com
Glutamine is the primary metabolite of nitrogen assimilation from inorganic nitrogen sources
in microorganisms and plants. The ability to monitor cellular nitrogen status is pivotal for …

Chemoproteomic identification of CO2-dependent lysine carboxylation in proteins

DT King, S Zhu, DB Hardie, JE Serrano-Negrón… - Nature Chemical …, 2022 - nature.com
Carbon dioxide is an omnipresent gas that drives adaptive responses within organisms from
all domains of life. The molecular mechanisms by which proteins serve as sensors of CO2 …

Sensory properties of the PII signalling protein family

K Forchhammer, J Lüddecke - The FEBS journal, 2016 - Wiley Online Library
PII signalling proteins constitute one of the largest families of signalling proteins in nature.
An even larger superfamily of trimeric sensory proteins with the same architectural principle …