Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

Despite decades of intensive research, the biological mechanisms that causally underlie
depression are still unclear, and therefore the development of novel effective antidepressant …

In this paper, we integrate recent theoretical and empirical developments in predictive
coding and active inference accounts of interoception (including the Embodied Predictive …

Data from clinical and preclinical studies indicate that immune dysregulation, specifically of
inflammatory processes, is associated with symptoms of major depressive disorder (MDD) …

Accumulating evidence supports an association between depression and inflammatory
processes, a connection that seems to be bidirectional. Clinical trials have indicated …

Current diagnosis of depression is based solely on behavioral symptomatology. The
available US Food and Drug Administration–approved treatments for depression have come …

Major depression is a prevalent illness that increases the risk of several neurological
conditions. These include stroke, cardiovascular disease, and dementia including …

Diagnostic criteria for mood disorders including major depressive disorder (MDD) largely
ignore biological factors in favor of behavioral symptoms. Compounding this paucity of …

Women appear to be more vulnerable to the depressogenic effects of inflammation than
men. Chronic stress, one of the most pertinent risk factors of depression and anxiety, is …

Abstract Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with
significant clinical, social and financial impacts for patients and their communities. The …