Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

JS Loh, WQ Mak, LKS Tan, CX Ng, HH Chan… - Signal transduction and …, 2024 - nature.com
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

The gut microbiome in Alzheimer's disease: what we know and what remains to be explored

S Chandra, SS Sisodia, RJ Vassar - Molecular neurodegeneration, 2023 - Springer
Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …

Gut microbiome composition may be an indicator of preclinical Alzheimer's disease

AL Ferreiro, JH Choi, J Ryou, EP Newcomer… - Science translational …, 2023 - science.org
Alzheimer's disease (AD) pathology is thought to progress from normal cognition through
preclinical disease and ultimately to symptomatic AD with cognitive impairment. Recent work …

[HTML][HTML] The potential role of gut microbiota in Alzheimer's disease: from diagnosis to treatment

A Varesi, E Pierella, M Romeo, GB Piccini, C Alfano… - Nutrients, 2022 - mdpi.com
Gut microbiota is emerging as a key regulator of many disease conditions and its
dysregulation is implicated in the pathogenesis of several gastrointestinal and extraintestinal …

[HTML][HTML] Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP/PS1 mice

J Sun, Y Zhang, Y Kong, T Ye, Q Yu… - Brain, Behavior, and …, 2022 - Elsevier
Gut microbiota alterations might affect the development of Alzheimer's disease (AD) through
microbiota-derived metabolites. For example, microbiota-derived Indoles via tryptophan …

Short-chain fatty acids and human health: from metabolic pathways to current therapeutic implications

S Facchin, L Bertin, E Bonazzi, G Lorenzon… - Life, 2024 - mdpi.com
The gastrointestinal tract is home to trillions of diverse microorganisms collectively known as
the gut microbiota, which play a pivotal role in breaking down undigested foods, such as …

Gut microbiome-targeted therapies for Alzheimer's disease

T Zhang, G Gao, LY Kwok, Z Sun - Gut Microbes, 2023 - Taylor & Francis
The advent of highthroughput 'omics' technologies has improved our knowledge of gut
microbiome in human health and disease, including Alzheimer's disease (AD), a …

Association of dietary live microbes and nondietary prebiotic/probiotic intake with cognitive function in older adults: evidence from NHANES

H Tang, X Zhang, N Luo, J Huang… - The Journals of …, 2024 - academic.oup.com
Background The current study aims to examine association of dietary live microbes and
nondietary prebiotic/probiotic intake with cognitive function among older US adults …

Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidence

X Liu, Y Liu, J Liu, H Zhang, C Shan… - Neural Regeneration …, 2024 - journals.lww.com
A growing body of evidence suggests that the gut microbiota contributes to the development
of neurodegenerative diseases via the microbiota-gut-brain axis. As a contributing factor …

Gut microbiota-host lipid crosstalk in Alzheimer's disease: implications for disease progression and therapeutics

YX Luo, LL Yang, XQ Yao - Molecular Neurodegeneration, 2024 - Springer
Trillions of intestinal bacteria in the human body undergo dynamic transformations in
response to physiological and pathological changes. Alterations in their composition and …