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The WNT/ROR pathway in cancer: from signaling to therapeutic intervention
K Menck, S Heinrichs, C Baden, A Bleckmann - Cells, 2021 - mdpi.com
The WNT pathway is one of the major signaling cascades frequently deregulated in human
cancer. While research had initially focused on signal transduction centered on β-catenin as …
cancer. While research had initially focused on signal transduction centered on β-catenin as …
Tyrosine kinase ROR1 as a target for anti-cancer therapies
Y Zhao, D Zhang, Y Guo, B Lu, ZJ Zhao, X Xu… - Frontiers in …, 2021 - frontiersin.org
Receptor tyrosine kinase ROR1 plays an essential role in embryogenesis and is
overexpressed in many types of malignant tumors. Studies have demonstrated that it plays …
overexpressed in many types of malignant tumors. Studies have demonstrated that it plays …
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures
The WNT16 locus is a major determinant of cortical bone thickness and nonvertebral
fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced …
fracture risk in humans. The disability, mortality and costs caused by osteoporosis-induced …
[HTML][HTML] Therapeutic avenues in bone repair: Harnessing an anabolic osteopeptide, PEPITEM, to boost bone growth and prevent bone loss
The existing suite of therapies for bone diseases largely act to prevent further bone loss but
fail to stimulate healthy bone formation and repair. We describe an endogenous …
fail to stimulate healthy bone formation and repair. We describe an endogenous …
[HTML][HTML] Genetics implicates overactive osteogenesis in the development of diffuse idiopathic skeletal hyperostosis
Diffuse idiopathic skeletal hyperostosis (DISH) is a condition where adjacent vertebrae
become fused through formation of osteophytes. The genetic and epidemiological etiology …
become fused through formation of osteophytes. The genetic and epidemiological etiology …
A glance on the role of actin in osteogenic and adipogenic differentiation of mesenchymal stem cells
AU Khan, R Qu, T Fan, J Ouyang, J Dai - Stem cell research & therapy, 2020 - Springer
Mesenchymal stem cells (MSCs) have the capacity to differentiate into multiple lineages
including osteogenic and adipogenic lineages. An increasing number of studies have …
including osteogenic and adipogenic lineages. An increasing number of studies have …
Alternative Wnt pathways and receptors
In addition to activating β-catenin/TCF transcriptional complexes, Wnt proteins can elicit a
variety of other responses. These are often lumped together under the denominator …
variety of other responses. These are often lumped together under the denominator …
The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction
Receptor tyrosine kinases of the Ryk and Ror families were initially classified as orphan
receptors because their ligands were unknown. They are now known to contain functional …
receptors because their ligands were unknown. They are now known to contain functional …
Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates
B Mattes, Y Dang, G Greicius, LT Kaufmann… - Elife, 2018 - elifesciences.org
Signaling filopodia, termed cytonemes, are dynamic actin-based membrane structures that
regulate the exchange of signaling molecules and their receptors within tissues. However …
regulate the exchange of signaling molecules and their receptors within tissues. However …
Ror‐family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases
The Ror‐family receptor tyrosine kinases (RTKs) play crucial roles in the development of
various organs and tissues. In mammals, Ror2, a member of the Ror‐family RTKs, has been …
various organs and tissues. In mammals, Ror2, a member of the Ror‐family RTKs, has been …