The emerging awareness of the contribution of epigenetic processes to genome function in
health and disease is underpinned by decades of research in model systems. In particular …

Epidemiological evidence increasingly suggests that environmental exposures early in
development have a role in susceptibility to disease in later life. In addition, some of these …

Accumulating evidence converges on the possibility that chromosomes interact with each
other to regulate transcription in trans. To systematically explore the epigenetic dimension of …

Given that natural selection is so powerful at optimizing complex adaptations, why does it
seem unable to eliminate genes (susceptibility alleles) that predispose to common, harmful …

Parent-of-origin effects occur when the phenotypic effect of an allele depends on whether it
is inherited from the mother or the father. Several phenomena can cause parent-of-origin …

Traditional studies on the combined effects of genetics and the environment on individual
variation in disease susceptibility primarily focus on single nucleotide polymorphisms that …

Environmental influence on developmental plasticity impacts a wide diversity of animal life
from insects to humans. We now understand the epigenetic basis for many of these altered …

Imprinted genes play crucial roles in mammalian development and disruption of their
expression is associated with many human disorders including tumourigenesis; yet, the …

Imprinted genes–critical for growth, metabolism, and neuronal function–are expressed from
one parental allele. Parent-of-origin-dependent CpG methylation regulates this expression …

The development of cancer is driven by the accumulation of scores of alterations affecting
the structure and function of the genome. Equally important in this process are genetic …