Experimental applications and factors involved in validating thermal windows using infrared thermography to assess the health and thermostability of laboratory …

A Verduzco-Mendoza, A Bueno-Nava, D Wang… - Animals, 2021 - mdpi.com
Simple Summary Laboratory animals are fundamental in biomedical science and monitoring
their health and metabolic processes is essential to ensure their welfare and the quality of …

[HTML][HTML] A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness

H Zhang, Y Zhu, Z Liu, Y Peng, W Peng, L Tong… - Cell, 2022 - cell.com
The host-seeking activity of hematophagous arthropods is essential for arboviral
transmission. Here, we demonstrate that mosquito-transmitted flaviviruses can manipulate …

Enterobactin inhibits microbiota-dependent activation of AhR to promote bacterial sepsis in mice

RC Keskey, J **ao, S Hyoju, A Lam, D Kim… - Nature …, 2025 - nature.com
Sepsis is a major cause of morbidity and mortality, but our understanding of the mechanisms
underlying survival or susceptibility is limited. Here, as pathogens often subvert host defence …

Multipronged Micelles–Hydrogel for Targeted and Prolonged Drug Delivery in Chronic Wound Infections

Q Zhao, J Liu, S Liu, J Han, Y Chen… - … Applied Materials & …, 2022 - ACS Publications
Chronic diabetic wounds are a growing threat globally. Many aspects contribute to its
deterioration, including bacterial infection, unbalanced microenvironment, dysfunction of cell …

Novel Temperature‐Sensitive Hydrogel Promotes Wound Healing Through YAP and MEK‐Mediated Mechanosensitivity

Z Li, J Huang, Y Jiang, Y Liu, G Qu… - Advanced …, 2022 - Wiley Online Library
Wound healing is a significant problem in clinical management. Various functional dressings
are studied to promote wound healing through biochemical factors. They are generally …

Systemic inflammation induced the delayed reduction of excitatory synapses in the CA3 during ageing

T Manabe, I Rácz, S Schwartz, L Oberle… - Journal of …, 2021 - Wiley Online Library
Sepsis‐associated encephalopathy (SAE) represents diverse cerebral dysfunctions in
response to pathogen‐induced systemic inflammation. Peripheral exposure to …

Refining humane endpoints in mouse models of disease by systematic review and machine learning-based endpoint definition

J Mei, S Banneke, J Lips, MTC Kuffner… - ALTEX: Alternatives …, 2019 - refubium.fu-berlin.de
Ideally, humane endpoints allow for early termination of experiments by minimizing an
animal's discomfort, distress and pain, while ensuring that scientific objectives are reached …

Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes

P Megagiannis, Y Mei, RE Yan, L Yuan, JJ Wilde… - Cell Reports, 2024 - cell.com
Reactive changes of glial cells during neuroinflammation impact brain disorders and
disease progression. Elucidating the mechanisms that control reactive gliosis may help us to …

Genetically encoded protein thermometer enables precise electrothermal control of transgene expression

BA Stefanov, AP Teixeira, M Mansouri… - Advanced …, 2021 - Wiley Online Library
Body temperature is maintained at around 37° C in humans, but may rise to 40° C or more
during high‐grade fever, which occurs in most adults who are seriously ill. However …

Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection

B Zhu, Y Wu, S Huang, R Zhang, YM Son, C Li… - Immunity, 2021 - cell.com
Tissue macrophages self-renew during homeostasis and produce inflammatory mediators
upon microbial infection. We examined the relationship between proliferative and …