Parkinson's disease prevalence is rapidly increasing in an aging global population. With this
increase comes exponentially rising social and economic costs, emphasizing the immediate …

Geroscience, the new interdisciplinary field that aims to understand the relationship between
aging and chronic age-related diseases (ARDs) and geriatric syndromes (GSs), is based on …

Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …

Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …

Lewy bodies commonly occur in Alzheimer's disease, and Alzheimer's disease pathology is
frequent in Lewy body diseases, but the burden of co-pathologies across neurodegenerative …

Significant advances have been made uncovering the factors that render neurons
vulnerable in Parkinson's disease (PD). However, the critical pathogenic events leading to …

Neuronal cell death in the central nervous system has always been a challenging process to
decipher. In normal physiological conditions, neuronal cell death is restricted in the adult …

Importance The late effects of traumatic brain injury (TBI) are of great interest, but studies
characterizing these effects are limited. Objective To determine whether TBI with loss of …

As the second most common age related neurodegenerative disease after Alzheimer's
disease, the health, social and economic impact resulting from Parkinson's disease will …

Recent evidence indicates that sensory and motor changes may precede the cognitive
symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of …