Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …

Mitochondria are at the crossroads of several crucial cellular activities including: adenosine
triphosphate (ATP) generation via oxidative phosphorylation; the biosynthesis of heme …

Background Cigarette smoking is the major risk factor for COPD, leading to chronic airway
inflammation. We hypothesized that cigarette smoke induces structural and functional …

Age-related macular degeneration (AMD) is the leading cause of blindness among older
adults in the developed world. Although the pathological mechanisms have not been …

Mitochondrial DNA (mtDNA) encodes several key components of respiratory chain
complexes that produce cellular energy through oxidative phosphorylation. mtDNA is …

Recent evidence suggests mitochondrial dysfunction as a common early pathomechanism
in Alzheimer's disease integrating genetic factors related to enhanced amyloid-beta (Aß) …

Cellular senescence is the ultimate and irreversible loss of replicative capacity occurring in
primary somatic cell culture. It is triggered as a stereotypic response to unrepaired nuclear …

Cells challenged by photosensitized oxidations face strong redox stresses and rely on
autophagy to either survive or die. However, the use of macroautophagy/autophagy to …

Purpose.: Increasing evidence suggests a central role for mitochondrial (mt) dysfunction in
age-related macular degeneration (AMD). Previous proteomic data from the retinal pigment …

The mitochondrial electron transport chain plays an important role in energy production in
aerobic organisms and is also a significant source of reactive oxygen species that damage …