Allergic reactions to the beta-lactam antibiotics (penicillins, cephalosporins, carbapenems,
and monobactams) are a major factor limiting their use. Immediate hypersensitivity reactions …

The discovery of penicillin by Fleming led to tremendous benefits in clinical medicine.
Penicillin quickly became one of the most commonly prescribed drugs in the world. Despite …

The allergic reactions constitute the most common and significant side-effects ofpenicillin.
The major antigenic determinant in penicillin allergy, the penicilloyl group derived from the …

Adverse drug reactions (ADRs) result in major health problems in the United States in both
the inpatient and outpatient setting. ADRs are broadly categorized into predictable (type A …

Objective.—To establish (1) the prevalence of positive penicillin skin tests among
outpatients with well-defined but variable history of penicillin allergy and (2) the …

This guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA)
hypersensitivity was written by the German and Austrian professional associations for …

Skin testing for penicillin allergy with penicillin G (Pen G), penicilloic acid (PA), and
penicilloyl poly-l-lysine (PPL) was performed on 740 subjects, and the results were …

THE immunologic mechanisms of penicillin allergy are of interest to physicians, not only
because of their practical value but also because they can serve as a model for the study of …

Introduction: Idiosyncratic drug-induced agranulocytosis (IDIAG) is a life-threatening adverse
reaction characterized by an absolute neutrophil count< 500 cells/μl of blood. It shares many …

Judging from available data on penicillin allergy there appear to be multiple definable risk
factors for drug-induced immunopathology. The induction of a drug-specific immune …