▪ Abstract Great advances have been made in the past three decades in understanding the
molecular mechanics underlying protein synthesis in bacteria, but our understanding of the …

Translation termination in eukaryotes occurs in response to a stop codon in the ribosomal A-
site and requires two release factors (RFs), eRF1 and eRF3, which bind to the A-site as an …

Termination of protein synthesis occurs when a translating ribosome encounters one of
three universally conserved stop codons: UAA, UAG or UGA. Release factors recognize stop …

The poly (A) tail plays an important role in maintaining mRNA stability and influences
translation efficiency via binding with PABP. However, the impact of poly (A) tail length on …

Eukaryotic translation termination is triggered by peptide release factors eRF1 and eRF3.
Whereas eRF1 recognizes all three termination codons and induces hydrolysis of peptidyl …

Termination of translation in eukaryotes has focused recently on functional anatomy of
polypeptide chain release factor, eRF1, by using a variety of different approaches. The tight …

Translation termination in eukaryotes is mediated by two release factors, eRF1 and eRF3.
eRF1 recognizes each of the three stop codons (UAG, UAA, and UGA) and facilitates …

When a stop codon is at the 80S ribosomal A site, there are six nucleotides (+ 4 to+ 9)
downstream that are inferred to be occupying the mRNA channel. We examined the …

Cells respond to hypoxia by shifting cellular processes from general housekee** functions
to activating specialized hypoxia-response pathways. Oxygen plays an important role in …

Eukaryotic translation termination is mediated by two interacting release factors, eRF1 and
eRF3, which act cooperatively to ensure efficient stop codon recognition and fast …