The primate prefrontal cortex (PFC) subserves our highest order cognitive operations, and
yet is tremendously dependent on a precise neurochemical environment for proper …

It has been over 50 years since the original serotonin hypothesis was proposed by the
British Psychiatrist Alec Coppen. Recently, some authors have questioned the validity of the …

In this paper, we integrate recent theoretical and empirical developments in predictive
coding and active inference accounts of interoception (including the Embodied Predictive …

The “serotonin hypothesis” of clinical depression is almost 50 years old. At its simplest, the
hypothesis proposes that diminished activity of serotonin pathways plays a causal role in the …

The dorsal raphe nucleus (DRN) is involved in organizing reward-related behaviours;
however, it remains unclear how genetically defined neurons in the DRN of a freely …

Experiences affect mood, which in turn affects subsequent experiences. Recent studies
suggest two specific principles. First, mood depends on how recent reward outcomes differ …

The premise of the standard regulatory model,“homeostasis”, is flawed: the goal of
regulation is not to preserve constancy of the internal milieu. Rather, it is to continually adjust …

The brain reward circuit has a central role in reinforcing behaviors that are rewarding and
preventing behaviors that lead to punishment. Recent work has shown that the lateral …

Serotonin's function in the brain is unclear. One challenge in testing the numerous
hypotheses about serotonin's function has been observing the activity of identified …

Successful goal-directed behavior critically depends on performance monitoring, a set of
cognitive and affective functions determining whether adaptive control is needed and, if so …