Amyloid-type protein aggregation and prion-like properties of amyloids
This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …
an important hallmark of protein misfolding diseases and therefore have been investigated …
High-resolution probing of early events in amyloid-β aggregation related to Alzheimer's disease
In Alzheimer's disease (AD), soluble oligomers of amyloid-β (Aβ) are emerging as a crucial
entity in driving disease progression as compared to insoluble amyloid deposits. The lacuna …
entity in driving disease progression as compared to insoluble amyloid deposits. The lacuna …
Pathways of amyloid-β aggregation depend on oligomer shape
One of the main research topics related to Alzheimer's disease is the aggregation of the
amyloid-β peptide, which was shown to follow different pathways for the two major alloforms …
amyloid-β peptide, which was shown to follow different pathways for the two major alloforms …
Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer's amyloid beta
Soluble low-molecular-weight oligomers formed during the early aggregation of amyloid
peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we …
peptides have been hypothesized as a major toxic species of amyloidogenesis. Herein, we …
Origin of metastable oligomers and their effects on amyloid fibril self-assembly
F Hasecke, T Miti, C Perez, J Barton, D Schölzel… - Chemical …, 2018 - pubs.rsc.org
Assembly of rigid amyloid fibrils with their characteristic cross-β sheet structure is a
molecular signature of numerous neurodegenerative and non-neuropathic disorders …
molecular signature of numerous neurodegenerative and non-neuropathic disorders …
Structural insights into curli CsgA cross-β fibril architecture inspire repurposing of anti-amyloid compounds as anti-biofilm agents
S Perov, O Lidor, N Salinas, N Golan… - PLoS …, 2019 - journals.plos.org
Curli amyloid fibrils secreted by Enterobacteriaceae mediate host cell adhesion and
contribute to biofilm formation, thereby promoting bacterial resistance to environmental …
contribute to biofilm formation, thereby promoting bacterial resistance to environmental …
Arginine and arginine-rich peptides as modulators of protein aggregation and cytotoxicity associated with Alzheimer's disease
A substantial body of evidence indicates cationic, arginine-rich peptides (CARPs) are
effective therapeutic compounds for a range of neurodegenerative pathologies, with …
effective therapeutic compounds for a range of neurodegenerative pathologies, with …
Tetrameric Aβ40 and Aβ42 β-barrel structures by extensive atomistic simulations. II. In aqueous solution
PH Nguyen, JM Campanera, ST Ngo… - The Journal of …, 2019 - ACS Publications
Alzheimer's disease (AD) is characterized by the accumulation of extracellular Aβ42 and
Aβ40 oligomers and plaques. In a recent computational study, we found that the presence of …
Aβ40 oligomers and plaques. In a recent computational study, we found that the presence of …
Antimicrobial α-defensins as multi-target inhibitors against amyloid formation and microbial infection
Amyloid aggregation and microbial infection are considered as pathological risk factors for
develo** amyloid diseases, including Alzheimer's disease (AD), type II diabetes (T2D) …
develo** amyloid diseases, including Alzheimer's disease (AD), type II diabetes (T2D) …
An organic electrochemical transistor integrated with a molecularly selective isoporous membrane for amyloid-β detection
Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with
severe memory loss and impaired cognitive skills. A common pathological change found in …
severe memory loss and impaired cognitive skills. A common pathological change found in …