Microtubule dynamics and their control are essential for the normal function and division of
all eukaryotic cells. This plethora of functions is, in large part, supported by dynamic …

Microtubules are dynamic polymers of αβ-tubulin that are essential for intracellular
organization, organelle trafficking and chromosome segregation. Microtubule growth and …

Microtubule (MT) filaments, composed of α/β-tubulin dimers, are fundamental to cellular
architecture, function and organismal development. They are nucleated from MT organizing …

Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …

Microtubule-targeting agents (MTAs) such as paclitaxel and the vinca alkaloids are among
the most important medical weapons available to combat cancer. MTAs interfere with …

Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

Dynamic instability, the stochastic switching between growth and shrinkage, is essential for
microtubule function. This behavior is driven by GTP hydrolysis in the microtubule lattice and …

3D cryo-electron microscopy (cryo-EM) is an expanding structural biology technique that has
recently undergone a quantum leap progression in its achievable resolution and its …

Microtubule-stabilizing agents (MSAs) are efficacious chemotherapeutic drugs widely used
for the treatment of cancer. Despite the importance of MSAs for medical applications and …

Microtubules are cytoskeletal filaments central to a wide range of essential cellular functions
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …