Induced pluripotent stem cell (iPSC) technologies have provided in vitro models of
inaccessible human cell types, yielding new insights into disease mechanisms especially for …

Reconstructing lineage relationships between cells within a tissue or organism is a long-
standing aim in biology. Traditionally, lineage tracing has been achieved through the …

The delayed and prolonged postmitotic maturation of human neurons, compared with
neurons from other species, may contribute to human-specific cognitive abilities and …

Parkinson's disease (PD) is the second most prevalent neurological disorder and has been
the focus of intense investigations to understand its etiology and progression, but it still lacks …

Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …

Light profoundly affects our mental and physical health. In particular, light, when not
delivered at the appropriate time, may have detrimental effects. In mammals, light is …

A comprehensive characterization of neuronal cell types, their distributions, and patterns of
connectivity is critical for understanding the properties of neural circuits and how they …

Organoids are systems derived from pluripotent stem cells at the interface between
traditional monolayer cultures and in vivo animal models. The structural and functional …

Induced pluripotent stem cells (iPSCs), and cells derived from them, have become key tools
for modeling biological processes, particularly in cell types that are difficult to obtain from …

Progenitors of the develo** human neocortex reside in the ventricular and outer
subventricular zones (VZ and OSVZ, respectively). However, whether cells derived from …