Strategically managing learning during perceptual decision making
Making optimal decisions in the face of noise requires balancing short-term speed and
accuracy. But a theory of optimality should account for the fact that short-term speed can …
accuracy. But a theory of optimality should account for the fact that short-term speed can …
Noradrenergic alpha-2a receptor stimulation enhances prediction error signaling and updating of attention sets in anterior cingulate cortex and striatum
The noradrenergic system is believed to support behavioral flexibility. A possible source
mediating improved flexibility are α2A adrenoceptors (α2AR) in prefrontal cortex (PFC) or …
mediating improved flexibility are α2A adrenoceptors (α2AR) in prefrontal cortex (PFC) or …
General mechanisms of task engagement in the primate frontal cortex
Staying engaged is necessary to maintain goal-directed behaviors. Despite this,
engagement exhibits continuous, intrinsic fluctuations. Even in experimental settings …
engagement exhibits continuous, intrinsic fluctuations. Even in experimental settings …
[HTML][HTML] On the role of behavioural modes during temporally extended decision-making and their neural substrates
Highlights●New advances in computational modelling, experimental design and theory
allow us to increasingly tackle complex decision problems.●Real-world decision-making …
allow us to increasingly tackle complex decision problems.●Real-world decision-making …
A causal role of the right dorsolateral prefrontal cortex in random exploration
Decision to explore new options with uncertain outcomes or exploit familiar options with
known outcomes is a fundamental challenge that the brain faces in almost all real-life …
known outcomes is a fundamental challenge that the brain faces in almost all real-life …
Decision-Making, Pro-variance Biases and Mood-Related Traits
W Lin, RJ Dolan - Computational Psychiatry, 2024 - pmc.ncbi.nlm.nih.gov
In value-based decision-making there is wide behavioural variability in how individuals
respond to uncertainty. Maladaptive responses to uncertainty have been linked to a …
respond to uncertainty. Maladaptive responses to uncertainty have been linked to a …
Distinct roles of the orbitofrontal cortex, ventral striatum, and dopamine neurons in counterfactual thinking of decision outcomes
Individuals often assess past decisions by comparing what was gained with what would
have been gained had they acted differently. Thoughts of past alternatives that counter what …
have been gained had they acted differently. Thoughts of past alternatives that counter what …
Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism
N Prince, LN Peralta Marzal, L Roussin, M Monnoye… - Gut …, 2025 - Taylor & Francis
Several factors are linked to the pathophysiology of autism spectrum disorders (ASD);
however, the molecular mechanisms of the condition remain unknown. As intestinal …
however, the molecular mechanisms of the condition remain unknown. As intestinal …
Neurons in the monkey frontopolar cortex encode learning stage and goal during a fast learning task
The frontopolar cortex (FPC) is, to date, one of the least understood regions of the prefrontal
cortex. The current understanding of its function suggests that it plays a role in the control of …
cortex. The current understanding of its function suggests that it plays a role in the control of …
Performance errors during rodent learning reflect a dynamic choice strategy
Humans, even as infants, use cognitive strategies, such as exploration and hypothesis
testing, to learn about causal interactions in the environment. In animal learning studies …
testing, to learn about causal interactions in the environment. In animal learning studies …