Herpesviruses are ubiquitous, double-stranded DNA, enveloped viruses that establish
lifelong infections and cause a range of diseases. Entry into host cells requires binding of …

The past few years have brought substantial progress toward understanding how human
cytomegalovirus (HCMV) enters the remarkably wide spectrum of cell types and tissues that …

Herpesvirus gH/gL envelope glycoprotein complexes are key players in virus entry as
ligands for host cell receptors and by promoting fusion of viral envelopes with cellular …

Interaction between gH/gL and the fusion protein gB is likely a conserved feature of the entry
mechanism for all herpesviruses. Human cytomegalovirus (HCMV) gH/gL can be bound by …

Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant
patients and the leading viral cause of birth defects after congenital infection. The …

Human cytomegalovirus (HCMV) can cause severe diseases in fetuses, newborns, and
immunocompromised individuals. Currently, no vaccines are approved, and treatment …

Human cytomegalovirus (HCMV) exhibits surprisingly high genomic diversity during natural
infection although little is known about the limits or patterns of HCMV diversity among …

Human Cytomegalovirus (HCMV) utilizes two different pathways for host cell entry. HCMV
entry into fibroblasts requires glycoproteins gB and gH/gL, whereas HCMV entry into …

Human cytomegalovirus (HCMV) poses a significant threat to immunocompromised
individuals and neonates infected in utero. Glycoprotein B (gB), the herpesvirus fusion …

Human cytomegalovirus (HCMV) strains that have been passaged in vitro rapidly acquire
mutations that impact viral growth. These laboratory-adapted strains of HCMV generally …