Multi-omics data integration, interpretation, and its application
I Subramanian, S Verma, S Kumar… - … and biology insights, 2020 - journals.sagepub.com
To study complex biological processes holistically, it is imperative to take an integrative
approach that combines multi-omics data to highlight the interrelationships of the involved …
approach that combines multi-omics data to highlight the interrelationships of the involved …
Gene regulatory network inference resources: A practical overview
Transcriptional regulation is a fundamental molecular mechanism involved in almost every
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …
The DNA methylation landscape of advanced prostate cancer
Although DNA methylation is a key regulator of gene expression, the comprehensive
methylation landscape of metastatic cancer has never been defined. Through whole …
methylation landscape of metastatic cancer has never been defined. Through whole …
LinkedOmics: analyzing multi-omics data within and across 32 cancer types
The LinkedOmics database contains multi-omics data and clinical data for 32 cancer types
and a total of 11 158 patients from The Cancer Genome Atlas (TCGA) project. It is also the …
and a total of 11 158 patients from The Cancer Genome Atlas (TCGA) project. It is also the …
TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data
Abstract The Cancer Genome Atlas (TCGA) research network has made public a large
collection of clinical and molecular phenotypes of more than 10 000 tumor patients across …
collection of clinical and molecular phenotypes of more than 10 000 tumor patients across …
Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data
W Yang, NM Warrington, SJ Taylor… - Science translational …, 2019 - science.org
Sex differences in the incidence and outcome of human disease are broadly recognized but,
in most cases, not sufficiently understood to enable sex-specific approaches to treatment …
in most cases, not sufficiently understood to enable sex-specific approaches to treatment …
ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression
The c-Myc oncogene drives malignant progression and induces robust anabolic and
proliferative programmes leading to intrinsic stress. The mechanisms enabling adaptation to …
proliferative programmes leading to intrinsic stress. The mechanisms enabling adaptation to …
M1-like tumor-associated macrophages activated by exosome-transferred THBS1 promote malignant migration in oral squamous cell carcinoma
M **ao, J Zhang, W Chen, W Chen - Journal of Experimental & Clinical …, 2018 - Springer
Background Treatment strategies targeting tumor-associated macrophages (TAMs) have
been proposed in cancer areas. The functional alterations of macrophages in the …
been proposed in cancer areas. The functional alterations of macrophages in the …
Exosomal miR-21-5p derived from gastric cancer promotes peritoneal metastasis via mesothelial-to-mesenchymal transition
Q Li, B Li, Q Li, S Wei, Z He, X Huang, L Wang… - Cell death & …, 2018 - nature.com
Peritoneal metastasis is a primary metastatic route for gastric cancers, and the mechanisms
underlying this process are still unclear. Peritoneal mesothelial cells (PMCs) undergo …
underlying this process are still unclear. Peritoneal mesothelial cells (PMCs) undergo …
Fast dimension reduction and integrative clustering of multi-omics data using low-rank approximation: application to cancer molecular classification
Background One major goal of large-scale cancer omics study is to identify molecular
subtypes for more accurate cancer diagnoses and treatments. To deal with high …
subtypes for more accurate cancer diagnoses and treatments. To deal with high …