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Inhibition of cancer development by natural plant polyphenols: Molecular mechanisms
A Lyubitelev, V Studitsky - International Journal of Molecular Sciences, 2023 - mdpi.com
Malignant tumors remain one of the main sources of morbidity and mortality around the
world. A chemotherapeutic approach to cancer treatment poses a multitude of challenges …
world. A chemotherapeutic approach to cancer treatment poses a multitude of challenges …
Contribution of the gut microbiome to drug disposition, pharmacokinetic and pharmacodynamic variability
The trillions of microbes that make up the gut microbiome are an important contributor to
health and disease. With respect to xenobiotics, particularly orally administered compounds …
health and disease. With respect to xenobiotics, particularly orally administered compounds …
[HTML][HTML] Interactions of resveratrol and its metabolites (resveratrol-3-sulfate, resveratrol-3-glucuronide, and dihydroresveratrol) with serum albumin, cytochrome P450 …
Resveratrol (RES) is a widely-known natural polyphenol which is also contained by several
dietary supplements. Large doses of RES can result in high micromolar levels of its sulfate …
dietary supplements. Large doses of RES can result in high micromolar levels of its sulfate …
[HTML][HTML] Interaction of luteolin, naringenin, and their sulfate and glucuronide conjugates with human serum albumin, cytochrome P450 (CYP2C9, CYP2C19, and …
Luteolin and naringenin are flavonoids found in various foods/beverages and present in
certain dietary supplements. After a high intake of these flavonoids, their sulfate and …
certain dietary supplements. After a high intake of these flavonoids, their sulfate and …
Effects of chrysin and its major conjugated metabolites chrysin-7-sulfate and chrysin-7-glucuronide on cytochrome P450 enzymes and on OATP, P-gp, BCRP, and …
Chrysin is an abundant flavonoid in nature, and it is also contained by several dietary
supplements. Chrysin is highly biotransformed in the body, during which conjugated …
supplements. Chrysin is highly biotransformed in the body, during which conjugated …
Interaction of Fumonisin B1, N-Palmitoyl-Fumonisin B1, 5-O-Palmitoyl-Fumonisin B1, and Fumonisin B4 Mycotoxins with Human Serum Albumin and Their Toxic …
Fumonisins are frequent food contaminants. The high exposure to fumonisins can cause
harmful effects in humans and animals. Fumonisin B1 (FB1) is the most typical member of …
harmful effects in humans and animals. Fumonisin B1 (FB1) is the most typical member of …
[HTML][HTML] Application of omics technology to investigate the mechanism underlying the role of San Hua Tang in regulating microglia polarization and blood-brain barrier …
S Luo, Y Chen, R Zhao, D Ma, Y Zhao, Y Zhang… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacology relevance San Hua Tang (SHT) was first mentioned in the
book" The Collection of Plain Questions about Pathogenesis, Qi, and Life." SHT has the …
book" The Collection of Plain Questions about Pathogenesis, Qi, and Life." SHT has the …
[HTML][HTML] Inhibition of xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation by luteolin, naringenin, myricetin, ampelopsin and their conjugated …
Luteolin, naringenin, myricetin, and ampelopsin are abundant flavonoids in nature, and
several dietary supplements also contain them at very high doses. After the peroral intake …
several dietary supplements also contain them at very high doses. After the peroral intake …
[HTML][HTML] The interaction of temozolomide with blood components suggests the potential use of human serum albumin as a biomimetic carrier for the drug
M Rubio-Camacho, JA Encinar, MJ Martínez-Tomé… - Biomolecules, 2020 - mdpi.com
The interaction of temozolomide (TMZ)(the main chemotherapeutic agent for brain tumors)
with blood components has not been studied at the molecular level to date, even though …
with blood components has not been studied at the molecular level to date, even though …
[HTML][HTML] Testing serum albumins and cyclodextrins as potential binders of the mycotoxin metabolites alternariol-3-sulfate, alternariol-9-monomethylether and …
Alternaria mycotoxins, including alternariol (AOH), alternariol-9-monomethylether (AME),
and their masked/modified derivatives (eg, sulfates or glycosides), are common food …
and their masked/modified derivatives (eg, sulfates or glycosides), are common food …