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Ageing and the pathogenesis of osteoarthritis
RF Loeser, JA Collins, BO Diekman - Nature Reviews Rheumatology, 2016 - nature.com
Ageing-associated changes that affect articular tissues promote the development of
osteoarthritis (OA). Although ageing and OA are closely linked, they are independent …
osteoarthritis (OA). Although ageing and OA are closely linked, they are independent …
The role of metabolism in the pathogenesis of osteoarthritis
Metabolism is important for cartilage and synovial joint function. Under adverse
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …
Osteoarthritis: a disease of the joint as an organ
RF Loeser, SR Goldring, CR Scanzello… - Arthritis and …, 2012 - pmc.ncbi.nlm.nih.gov
Osteoarthritis (OA) is the most common form of arthritis and a major cause of pain and
disability in older adults (1). Often OA is referred to as degenerative joint disease “(DJD)” …
disability in older adults (1). Often OA is referred to as degenerative joint disease “(DJD)” …
Effects of aging on articular cartilage homeostasis
M Lotz, RF Loeser - Bone, 2012 - Elsevier
This review is focused on aging-related changes in cells and extracellular matrix of the
articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage …
articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage …
Cartilage regeneration and ageing: targeting cellular plasticity in osteoarthritis
Ageing processes play a major contributing role for the development of Osteoarthritis (OA).
This prototypic degenerative condition of ageing is the most common form of arthritis and is …
This prototypic degenerative condition of ageing is the most common form of arthritis and is …
Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes
T Kato, S Miyaki, H Ishitobi, Y Nakamura… - Arthritis research & …, 2014 - Springer
Introduction Osteoarthritis (OA) is a whole joint disease, and characterized by progressive
degradation of articular cartilage, synovial hyperplasia, bone remodeling and angiogenesis …
degradation of articular cartilage, synovial hyperplasia, bone remodeling and angiogenesis …
Aging processes and the development of osteoarthritis
RF Loeser - Current opinion in rheumatology, 2013 - journals.lww.com
Current Opinion in Rheumatology Log in or Register Subscribe to journalSubscribe Get new
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[HTML][HTML] Intraarticular ligament degeneration is interrelated with cartilage and bone destruction in osteoarthritis
G Schulze-Tanzil - Cells, 2019 - mdpi.com
Osteoarthritis (OA) induces inflammation and degeneration of all joint components including
cartilage, joint capsule, bone and bone marrow, and ligaments. Particularly intraarticular …
cartilage, joint capsule, bone and bone marrow, and ligaments. Particularly intraarticular …
Improved deep convolutional neural network to classify osteoarthritis from anterior cruciate ligament tear using magnetic resonance imaging
Anterior cruciate ligament (ACL) tear is caused by partially or completely torn ACL ligament
in the knee, especially in sportsmen. There is a need to classify the ACL tear before it fully …
in the knee, especially in sportsmen. There is a need to classify the ACL tear before it fully …
Tendons and ligaments: connecting developmental biology to musculoskeletal disease pathogenesis
Tendons and ligaments provide connections between muscle and bone or bone and bone
to enable locomotion. Damage to tendons and ligaments caused by acute or chronic injury …
to enable locomotion. Damage to tendons and ligaments caused by acute or chronic injury …