Ageing and the pathogenesis of osteoarthritis

RF Loeser, JA Collins, BO Diekman - Nature Reviews Rheumatology, 2016 - nature.com
Ageing-associated changes that affect articular tissues promote the development of
osteoarthritis (OA). Although ageing and OA are closely linked, they are independent …

The role of metabolism in the pathogenesis of osteoarthritis

A Mobasheri, MP Rayman, O Gualillo… - Nature Reviews …, 2017 - nature.com
Metabolism is important for cartilage and synovial joint function. Under adverse
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …

Osteoarthritis: a disease of the joint as an organ

RF Loeser, SR Goldring, CR Scanzello… - Arthritis and …, 2012 - pmc.ncbi.nlm.nih.gov
Osteoarthritis (OA) is the most common form of arthritis and a major cause of pain and
disability in older adults (1). Often OA is referred to as degenerative joint disease “(DJD)” …

Effects of aging on articular cartilage homeostasis

M Lotz, RF Loeser - Bone, 2012 - Elsevier
This review is focused on aging-related changes in cells and extracellular matrix of the
articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage …

Cartilage regeneration and ageing: targeting cellular plasticity in osteoarthritis

M Varela-Eirin, J Loureiro, E Fonseca… - Ageing research …, 2018 - Elsevier
Ageing processes play a major contributing role for the development of Osteoarthritis (OA).
This prototypic degenerative condition of ageing is the most common form of arthritis and is …

Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes

T Kato, S Miyaki, H Ishitobi, Y Nakamura… - Arthritis research & …, 2014 - Springer
Introduction Osteoarthritis (OA) is a whole joint disease, and characterized by progressive
degradation of articular cartilage, synovial hyperplasia, bone remodeling and angiogenesis …

Aging processes and the development of osteoarthritis

RF Loeser - Current opinion in rheumatology, 2013 - journals.lww.com
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[HTML][HTML] Intraarticular ligament degeneration is interrelated with cartilage and bone destruction in osteoarthritis

G Schulze-Tanzil - Cells, 2019 - mdpi.com
Osteoarthritis (OA) induces inflammation and degeneration of all joint components including
cartilage, joint capsule, bone and bone marrow, and ligaments. Particularly intraarticular …

Improved deep convolutional neural network to classify osteoarthritis from anterior cruciate ligament tear using magnetic resonance imaging

MJ Awan, MSM Rahim, N Salim, A Rehman… - Journal of Personalized …, 2021 - mdpi.com
Anterior cruciate ligament (ACL) tear is caused by partially or completely torn ACL ligament
in the knee, especially in sportsmen. There is a need to classify the ACL tear before it fully …

Tendons and ligaments: connecting developmental biology to musculoskeletal disease pathogenesis

H Asahara, M Inui, MK Lotz - Journal of Bone and Mineral …, 2017 - academic.oup.com
Tendons and ligaments provide connections between muscle and bone or bone and bone
to enable locomotion. Damage to tendons and ligaments caused by acute or chronic injury …