Pathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion

MA Samuel, MS Diamond - Journal of virology, 2006 - Am Soc Microbiol
West Nile virus (WNV) is a neurotropic ffavivirus that has emerged globally as a significant
cause of viral encephalitis. WNV is maintained in an enzootic cycle between mosquitoes …

Domain III peptides from flavivirus envelope protein are useful antigens for serologic diagnosis and targets for immunization

JH Chávez, JR Silva, AA Amarilla, LTM Figueiredo - Biologicals, 2010 - Elsevier
The Flavivirus genus of the Flaviviridae family includes 70 enveloped single-stranded-RNA
positive-sense viruses transmitted by arthropods. Among these viruses, there are a relevant …

Development of a humanized monoclonal antibody with therapeutic potential against West Nile virus

T Oliphant, M Engle, GE Nybakken, C Doane… - Nature medicine, 2005 - nature.com
Abstract Neutralization of West Nile virus (WNV) in vivo correlates with the development of
an antibody response against the viral envelope (E) protein. Using random mutagenesis …

Type-and subcomplex-specific neutralizing antibodies against domain III of dengue virus type 2 envelope protein recognize adjacent epitopes

S Sukupolvi-Petty, SK Austin, WE Purtha… - Journal of …, 2007 - Am Soc Microbiol
Neutralization of flaviviruses in vivo correlates with the development of an antibody
response against the viral envelope (E) protein. Previous studies demonstrated that …

The development of therapeutic antibodies that neutralize homologous and heterologous genotypes of dengue virus type 1

B Shrestha, JD Brien, S Sukupolvi-Petty… - PLoS …, 2010 - journals.plos.org
Antibody protection against flaviviruses is associated with the development of neutralizing
antibodies against the viral envelope (E) protein. Prior studies with West Nile virus (WNV) …

Infectious cDNA clone of the epidemic West Nile virus from New York City

PY Shi, M Tilgner, MK Lo, KA Kent… - Journal of virology, 2002 - Am Soc Microbiol
We report the first full-length infectious clone of the current epidemic, lineage I, strain of West
Nile virus (WNV). The full-length cDNA was constructed from reverse transcription-PCR …

Structural basis of a flavivirus recognized by its neutralizing antibody: solution structure of the domain III of the Japanese encephalitis virus envelope protein

KP Wu, CW Wu, YP Tsao, TW Kuo, YC Lou… - Journal of Biological …, 2003 - ASBMB
The flavivirus envelope protein is the dominant antigen in eliciting neutralizing antibodies
and plays an important role in inducing immunologic responses in the infected host. We …

A functional epitope determinant on domain III of the Japanese encephalitis virus envelope protein interacted with neutralizing-antibody combining sites

CW Lin, SC Wu - Journal of virology, 2003 - Am Soc Microbiol
The envelope (E) protein of Japanese encephalitis virus (JEV) is associated with viral
binding to cellular receptors, membrane fusion, and the induction of protective neutralizing …

Screening of protective antigens of Japanese encephalitis virus by DNA immunization: a comparative study with conventional viral vaccines

HW Chen, CH Pan, MY Liau, R Jou, CJ Tsai… - Journal of …, 1999 - Am Soc Microbiol
In this study, we evaluated the relative role of the structural and nonstructural proteins of the
Japanese encephalitis virus (JEV) in inducing protective immunities and compared the …

Structural and molecular analyses of functional epitopes and escape mutants in Japanese encephalitis virus envelope protein domain III

U Roy - Immunologic Research, 2020 - Springer
The Japanese encephalitis virus (JEV) is one of the vector borne causes of encephalitis
found in southeastern Asia. This positive single-stranded RNA virus is a member of the …