The past 15 years have seen an explosion in our understanding of how cells replicate
damaged DNA and how this can lead to mutagenesis. The Y-family DNA polymerases lie at …

The different ultraviolet (UV) wavelength components, UVA (320–400nm), UVB (280–
320nm), and UVC (200–280nm), have distinct mutagenic properties. A hallmark of UVC and …

▪ Abstract This review focuses on eukaryotic translesion synthesis (TLS) DNA polymerases,
and the emphasis is on Saccharomyces cerevisiae and human Y-family polymerases (Pols) …

Ultraviolet (UV) light induces specific mutations in the cellular and skin genome such as UV-
signature and triplet mutations, the mechanism of which has been thought to involve …

There are 15 different DNA polymerases encoded in mammalian genomes, which are
specialized for replication, repair or the tolerance of DNA damage. New evidence is …

When describing the structure of the DNA double helix, Watson and Crick (1) wrote,“It has
not escaped our notice that the specific pairing we have postulated immediately suggests a …

Thousands of apurinic/apyrimidinic (AP or abasic) sites form in each cell, each day. This
simple DNA lesion can have profound consequences to cellular function, genome stability …

Ultraviolet (UV) irradiation causes various types of DNA damage, which leads to specific
mutations and the emergence of skin cancer in humans, often decades after initial exposure …

The number of DNA polymerases identified in each organism has mushroomed in the past
two decades. Most newly found DNA polymerases specialize in translesion synthesis and …

▪ Abstract DNA repair is crucial to the well-being of all organisms from unicellular life forms to
humans. A rich tapestry of mechanistic studies on DNA repair has emerged thanks to the …