Zebrafish larvae show a clear and distinct pattern of swimming in response to light and dark
conditions, following the development of a swim bladder at 4 days post fertilization. This …

After more than a century from its discovery, valproic acid (VPA) still represents one of the
most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a …

Autophagy is an essential degradation pathway in clearing abnormal protein aggregates in
mammalian cells and is responsible for protein homeostasis and neuronal health. Several …

Migraine is a neurological disorder that manifests as a debilitating headache associated
with altered sensory perception. The neuropeptide calcitonin gene-related peptide (CGRP) …

Dravet syndrome is a severe developmental and epileptic encephalopathy characterised by
refractory seizures and cognitive dysfunction. The treatment is challenging, not least …

Importance Posttraumatic stress disorder (PTSD) is a common psychiatric illness,
increasingly in the public spotlight in the United States due its prevalence in the soldiers …

Impairments in cognition are common in epilepsy and may be caused or exacerbated by
antiseizure medications (ASMs). Positive effects on cognition may also be seen with some …

Amyloidogenic processing of the amyloid precursor protein (APP) by β-and γ-secretases
generates several biologically active products, including amyloid-β (Aβ) and the APP …

J. Neurochem.(2012) 120 (Suppl. 1), 167–185. Abstract The amyloid cascade hypothesis of
Alzheimer's disease envisages that the initial elevation of amyloid β‐peptide (Aβ) levels …

Antiepileptic drugs (AEDs) are used to treat various nonepileptic central nervous system
(CNS) disorders, both in neurology and psychiatry. Most AEDs have multiple mechanisms of …